Polypeptide-based self-healing hydrogels: Design and biomedical applications

L Cai, S Liu, J Guo, YG Jia - Acta Biomaterialia, 2020 - Elsevier
Self-healing hydrogels can heal themselves on the damaged sites, which opens up a
fascinating way for enhancing lifetimes of materials. Polypeptide/poly (amino acid) is a class …

Helical polymers for biological and medical applications

T Leigh, P Fernandez-Trillo - Nature Reviews Chemistry, 2020 - nature.com
Helices are the most prevalent secondary structure in biomolecules and play vital roles in
their activity. Chemists have been fascinated with mimicking this molecular conformation …

Research progress on hydrogel materials and their antifouling properties

D Su, X Bai, X He - European Polymer Journal, 2022 - Elsevier
Hydrogel has good hydrophilicity, biocompatibility, stimuli responsiveness, and functionality,
which make it show great potential in the marine antifouling application, the fields of tissue …

Biomaterials via peptide assembly: Design, characterization, and application in tissue engineering

VP Gray, CD Amelung, IJ Duti, EG Laudermilch… - Acta biomaterialia, 2022 - Elsevier
A core challenge in biomaterials, with both fundamental significance and technological
relevance, concerns the rational design of bioactive microenvironments. Designed properly …

Lesion environments direct transplanted neural progenitors towards a wound repair astroglial phenotype in mice

TM O'shea, Y Ao, S Wang, AL Wollenberg… - Nature …, 2022 - nature.com
Neural progenitor cells (NPC) represent potential cell transplantation therapies for CNS
injuries. To understand how lesion environments influence transplanted NPC fate in vivo, we …

Sulfoxide‐containing polymer‐coated nanoparticles demonstrate minimal protein fouling and improved blood circulation

R Qiao, C Fu, Y Li, X Qi, D Ni, A Nandakumar… - Advanced …, 2020 - Wiley Online Library
Minimizing the interaction of nanomedicines with the mononuclear phagocytic system (MPS)
is a critical challenge for their clinical translation. Conjugating polyethylene glycol (PEG) to …

[HTML][HTML] Optimizing stem cell therapy after ischemic brain injury

S Zhang, BB Lachance, B Moiz, X Jia - Journal of Stroke, 2020 - ncbi.nlm.nih.gov
Stem cells have been used for regenerative and therapeutic purposes in a variety of
diseases. In ischemic brain injury, preclinical studies have been promising, but have failed …

Oxidation‐Responsive Materials: Biological Rationale, State of the Art, Multiple Responsiveness, and Open Issues

F El‐Mohtadi, R d'Arcy, N Tirelli - Macromolecular rapid …, 2019 - Wiley Online Library
In this review, a general introduction to biological oxidants (focusing on reactive oxygen
species, ROS) and the biomedical rationale behind the development of materials capable of …

Helix-specific properties and applications in synthetic polypeptides

N Li, Y Lei, Z Song, L Yin - Current Opinion in Solid State and Materials …, 2023 - Elsevier
Polypeptides obtained from the ring-opening polymerization of N-carboxyanhydrides, as the
synthetic analogues of natural proteins, have drawn broad interests during the recent three …

Proteins conjugated with sulfoxide-containing polymers show reduced macrophage cellular uptake and improved pharmacokinetics

Y Yu, W Xu, X Huang, X Xu, R Qiao, Y Li, F Han… - ACS Macro …, 2020 - ACS Publications
The conjugation of hydrophilic polymers to proteins is an effective approach to prolonging
their circulation time in the bloodstream and, hence, improving their delivery to the target …