Disturbed cholesterol homeostasis plays critical roles in the development of multiple
diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and …

Melittin is the principal toxic component in the venom of the European honey bee Apis
mellifera and is a cationic, hemolytic peptide. It is a small linear peptide composed of 26 …

The role of cholesterol in eukaryotic membrane protein function has been attributed primarily
to an influence on membrane fluidity and curvature. We present the 2.8 Å resolution crystal …

Cholesterol is necessary for the function of many G-protein coupled receptors (GPCRs). We
find that cholesterol is not just necessary but also sufficient to activate signaling by the …

Introduction to Proteins provides a comprehensive and state-of-the-art introduction to the
structure, function, and motion of proteins for students, faculty, and researchers at all levels …

G protein coupled receptors (GPCRs) form the largest receptor superfamily in eukaryotic
cells. Owing to their seven transmembrane helices, large parts of these proteins are …

The linear peptide gramicidin forms prototypical ion channels specific for monovalent
cations and has been extensively used to study the organization, dynamics and function of …

Cholesterol homeostasis is a highly regulated process in human body because of its several
functions underlying the biology of cell membranes, the synthesis of all steroid hormones …

Membrane proteins are still heavily under-represented in the protein data bank (PDB),
owing to multiple bottlenecks. The typical low abundance of membrane proteins in their …

There is evidence that lipids can be allosteric regulators of membrane protein structure and
activation. However, there are no data showing how exactly the regulation emerges from …