Bacterial quorum sensing during infection

S Azimi, AD Klementiev, M Whiteley… - Annual review of …, 2020 - annualreviews.org
Bacteria are highly interactive and possess an extraordinary repertoire of intercellular
communication and social behaviors, including quorum sensing (QS). QS has been studied …

Exploiting quorum sensing to confuse bacterial pathogens

B LaSarre, MJ Federle - Microbiology and molecular biology …, 2013 - Am Soc Microbiol
Cell-cell communication, or quorum sensing, is a widespread phenomenon in bacteria that
is used to coordinate gene expression among local populations. Its use by bacterial …

Evolution of the Pseudomonas aeruginosa quorum-sensing hierarchy

M Kostylev, DY Kim, NE Smalley… - Proceedings of the …, 2019 - National Acad Sciences
The bacterial pathogen Pseudomonas aeruginosa activates expression of many virulence
genes in a cell density-dependent manner by using an intricate quorum-sensing (QS) …

Quorum-sensing in Gram-negative bacteria

NA Whitehead, AML Barnard, H Slater… - FEMS microbiology …, 2001 - academic.oup.com
It has become increasingly and widely recognised that bacteria do not exist as solitary cells,
but are colonial organisms that exploit elaborate systems of intercellular communication to …

Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms

PK Singh, AL Schaefer, MR Parsek, TO Moninger… - Nature, 2000 - nature.com
The bacterium Pseudomonas aeruginosa permanently colonizes cystic fibrosis lungs
despite aggressive antibiotic treatment,,. This suggests that P. aeruginosa might exist as …

Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients

EE Smith, DG Buckley, Z Wu… - Proceedings of the …, 2006 - National Acad Sciences
In many human infections, hosts and pathogens coexist for years or decades. Important
examples include HIV, herpes viruses, tuberculosis, leprosy, and malaria. With the exception …

Sociomicrobiology: the connections between quorum sensing and biofilms

MR Parsek, EP Greenberg - Trends in microbiology, 2005 - cell.com
In the past decade, significant debate has surrounded the relative contributions of genetic
determinants versus environmental conditions to certain types of human behavior. While this …

Bacterial quorum sensing in pathogenic relationships

TR De Kievit, BH Iglewski - Infection and immunity, 2000 - Am Soc Microbiol
Bacteria were for a long time believed to exist as individual cells that sought primarily to find
nutrients and multiply. The discovery of intercellular communication among bacteria has led …

Roles of Pseudomonas aeruginosa las and rhl quorum-sensing systems in control of elastase and rhamnolipid biosynthesis genes

JP Pearson, EC Pesci, BH Iglewski - Journal of bacteriology, 1997 - Am Soc Microbiol
Two quorum-sensing systems (las and rhl) regulate virulence gene expression in
Pseudomonas aeruginosa. The las system consists of a transcriptional activator, LasR, and …

Why chronic wounds will not heal: a novel hypothesis

T Bjarnsholt, K Kirketerp‐Møller… - Wound repair and …, 2008 - Wiley Online Library
The present paper presents a hypothesis aimed at explaining why venous leg ulcers,
pressure ulcers, and diabetic foot ulcers develop into a chronic state. We propose that the …