COVID‐19 and toll‐like receptor 4 (TLR4): SARS‐CoV‐2 may bind and activate TLR4 to increase ACE2 expression, facilitating entry and causing hyperinflammation

MM Aboudounya, RJ Heads - Mediators of inflammation, 2021 - Wiley Online Library
Causes of mortality from COVID‐19 include respiratory failure, heart failure, and
sepsis/multiorgan failure. TLR4 is an innate immune receptor on the cell surface that …

[HTML][HTML] Environmental stressors on skin aging. Mechanistic insights

C Parrado, S Mercado-Saenz, A Perez-Davo… - Frontiers in …, 2019 - frontiersin.org
The skin is the main barrier that protects us against environmental stressors (physical,
chemical, and biological). These stressors, combined with internal factors, are responsible …

In silico studies on the comparative characterization of the interactions of SARS‐CoV‐2 spike glycoprotein with ACE‐2 receptor homologs and human TLRs

A Choudhury, S Mukherjee - Journal of medical virology, 2020 - Wiley Online Library
Abstract Coronavirus disease‐2019 (COVID‐19) outbreak due to novel coronavirus or
severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection has come out as …

[HTML][HTML] Zoonotic spillover: Understanding basic aspects for better prevention

JH Ellwanger, JAB Chies - Genetics and Molecular Biology, 2021 - SciELO Brasil
The transmission of pathogens from wild animals to humans is called “zoonotic spillover”.
Most human infectious diseases (60-75%) are derived from pathogens that originally …

[HTML][HTML] Therapeutic potential of ginger against COVID-19: Is there enough evidence?

A Jafarzadeh, S Jafarzadeh, M Nemati - Journal of Traditional Chinese …, 2021 - Elsevier
In addition to the respiratory system, severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) strikes other systems, including the digestive, circulatory, urogenital, and …

Toll‐like receptor polymorphism in host immune response to infectious diseases: A review

S Mukherjee, S Huda… - Scandinavian journal of …, 2019 - Wiley Online Library
Immunopolymorphism is considered as an important aspect behind the resistance or
susceptibility of the host to an infectious disease. Over the years, researchers have explored …

[HTML][HTML] Toll-like receptor-guided therapeutic intervention of human cancers: molecular and immunological perspectives

S Mukherjee, R Patra, P Behzadi, A Masotti… - Frontiers in …, 2023 - frontiersin.org
Toll-like receptors (TLRs) serve as the body's first line of defense, recognizing both
pathogen-expressed molecules and host-derived molecules released from damaged or …

Sulforaphane: its “coming of age” as a clinically relevant nutraceutical in the prevention and treatment of chronic disease

CA Houghton - Oxidative medicine and cellular longevity, 2019 - Wiley Online Library
A growing awareness of the mechanisms by which phytochemicals can influence upstream
endogenous cellular defence processes has led to intensified research into their potential …

[HTML][HTML] Antiviral and immunomodulatory effects of phytochemicals from honey against COVID-19: Potential mechanisms of action and future directions

MAI Al-Hatamleh, MM Hatmal, K Sattar, S Ahmad… - Molecules, 2020 - mdpi.com
The new coronavirus disease (COVID-19), caused by severe acute respiratory syndrome
coronavirus-2 (SARS-CoV-2), has recently put the world under stress, resulting in a global …

Targeting human TLRs to combat COVID‐19: a solution?

R Patra, N Chandra Das… - Journal of medical …, 2021 - search.ebscohost.com
Targeting human TLRs to combat COVID-19: A solution? The recent publication by
Choudhury and Mukherjee1 in this journal depicted the interactions of severe acute …