The bacterial translation stress response
Throughout their life, bacteria need to sense and respond to environmental stress. Thus,
such stress responses can require dramatic cellular reprogramming, both at the …
such stress responses can require dramatic cellular reprogramming, both at the …
[HTML][HTML] Coping with stress: how bacteria fine-tune protein synthesis and protein transport
Maintaining a functional proteome under different environmental conditions is challenging
for every organism, in particular for unicellular organisms, such as bacteria. In order to cope …
for every organism, in particular for unicellular organisms, such as bacteria. In order to cope …
Ribosome hibernation
T Prossliner, K Skovbo Winther… - Annual review of …, 2018 - annualreviews.org
Protein synthesis consumes a large fraction of available resources in the cell. When bacteria
encounter unfavorable conditions and cease to grow, specialized mechanisms are in place …
encounter unfavorable conditions and cease to grow, specialized mechanisms are in place …
The stringent response regulates adaptation to darkness in the cyanobacterium Synechococcus elongatus
RD Hood, SA Higgins, A Flamholz… - Proceedings of the …, 2016 - National Acad Sciences
The cyanobacterium Synechococcus elongatus relies upon photosynthesis to drive
metabolism and growth. During darkness, Synechococcus stops growing, derives energy …
metabolism and growth. During darkness, Synechococcus stops growing, derives energy …
Ribosome hibernation facilitates tolerance of stationary-phase bacteria to aminoglycosides
SL McKay, DA Portnoy - Antimicrobial agents and chemotherapy, 2015 - Am Soc Microbiol
Upon entry into stationary phase, bacteria dimerize 70S ribosomes into translationally
inactive 100S particles by a process called ribosome hibernation. Previously, we reported …
inactive 100S particles by a process called ribosome hibernation. Previously, we reported …
Hibernation factors directly block ribonucleases from entering the ribosome in response to starvation
T Prossliner, K Gerdes, MA Sørensen… - Nucleic Acids …, 2021 - academic.oup.com
Ribosome hibernation is a universal translation stress response found in bacteria as well as
plant plastids. The term was coined almost two decades ago and despite recent insights …
plant plastids. The term was coined almost two decades ago and despite recent insights …
[HTML][HTML] The cryo-EM structure of hibernating 100S ribosome dimer from pathogenic Staphylococcus aureus
D Matzov, S Aibara, A Basu, E Zimmerman… - Nature …, 2017 - nature.com
Formation of 100S ribosome dimer is generally associated with translation suppression in
bacteria. Trans-acting factors ribosome modulation factor (RMF) and hibernating promoting …
bacteria. Trans-acting factors ribosome modulation factor (RMF) and hibernating promoting …
Survival of the drowsiest: the hibernating 100S ribosome in bacterial stress management
In response to nutrient deprivation and environmental insults, bacteria conjoin two copies of
non-translating 70S ribosomes that form the translationally inactive 100S dimer. This …
non-translating 70S ribosomes that form the translationally inactive 100S dimer. This …
Structure of the Bacillus subtilis hibernating 100S ribosome reveals the basis for 70S dimerization
Under stress conditions, such as nutrient deprivation, bacteria enter into a hibernation stage,
which is characterized by the appearance of 100S ribosomal particles. In Escherichia coli …
which is characterized by the appearance of 100S ribosomal particles. In Escherichia coli …
Disassembly of the Staphylococcus aureus hibernating 100S ribosome by an evolutionarily conserved GTPase
The bacterial hibernating 100S ribosome is a poorly understood form of the dimeric 70S
particle that has been linked to pathogenesis, translational repression, starvation responses …
particle that has been linked to pathogenesis, translational repression, starvation responses …