Advances in targeted therapy for malignant lymphoma
L Wang, W Qin, YJ Huo, X Li, Q Shi… - Signal transduction and …, 2020 - nature.com
The incidence of lymphoma has gradually increased over previous decades, and it ranks
among the ten most prevalent cancers worldwide. With the development of targeted …
among the ten most prevalent cancers worldwide. With the development of targeted …
Diagnostic approaches and future directions in Burkitt lymphoma and high-grade B-cell lymphoma
Since the 2016 WHO update, progress has been made in understanding the biology of
Burkitt lymphoma (BL) and the concept of high-grade B-cell lymphomas (HGBCL) that allows …
Burkitt lymphoma (BL) and the concept of high-grade B-cell lymphomas (HGBCL) that allows …
Genomic profiling for clinical decision making in lymphoid neoplasms
L De Leval, AA Alizadeh, PL Bergsagel… - Blood, The Journal …, 2022 - ashpublications.org
With the introduction of large-scale molecular profiling methods and high-throughput
sequencing technologies, the genomic features of most lymphoid neoplasms have been …
sequencing technologies, the genomic features of most lymphoid neoplasms have been …
Noncoding mutations cause super-enhancer retargeting resulting in protein synthesis dysregulation during B cell lymphoma progression
Whole-genome sequencing of longitudinal tumor pairs representing transformation of
follicular lymphoma to high-grade B cell lymphoma with MYC and BCL2 rearrangements …
follicular lymphoma to high-grade B cell lymphoma with MYC and BCL2 rearrangements …
The double-hit signature identifies double-hit diffuse large B-cell lymphoma with genetic events cryptic to FISH
LK Hilton, J Tang, S Ben-Neriah… - Blood, The Journal …, 2019 - ashpublications.org
High-grade B-cell lymphomas with MYC and BCL2 and/or BCL6 rearrangements (HGBL-
DH/THs) include a group of diffuse large B-cell lymphomas (DLBCLs) with inferior outcomes …
DH/THs) include a group of diffuse large B-cell lymphomas (DLBCLs) with inferior outcomes …
Histone acetylation dynamics modulates chromatin conformation and allele-specific interactions at oncogenic loci
In cancer cells, enhancer hijacking mediated by chromosomal alterations and/or increased
deposition of acetylated histone H3 lysine 27 (H3K27ac) can support oncogene expression …
deposition of acetylated histone H3 lysine 27 (H3K27ac) can support oncogene expression …
Non-IG:: MYC in diffuse large B-cell lymphoma confers variable genomic configurations and MYC transactivation potential
C Zhang, E Stelloo, S Barrans, F Cucco, D Jiang… - Leukemia, 2024 - nature.com
Abstract MYC translocation occurs in 8–14% of diffuse large B-cell lymphoma (DLBCL), and
may concur with BCL2 and/or BCL6 translocation, known as double-hit (DH) or triple-hit …
may concur with BCL2 and/or BCL6 translocation, known as double-hit (DH) or triple-hit …
Genetic subdivisions of follicular lymphoma defined by distinct coding and noncoding mutation patterns
Follicular lymphoma (FL) accounts for∼ 20% of all new lymphoma cases. Increases in
cytological grade are a feature of the clinical progression of this malignancy, and eventual …
cytological grade are a feature of the clinical progression of this malignancy, and eventual …
Unscrambling cancer genomes via integrated analysis of structural variation and copy number
Complex somatic genomic rearrangements and copy number alterations are hallmarks of
nearly all cancers. We have developed an algorithm, LINX, to aid interpretation of structural …
nearly all cancers. We have developed an algorithm, LINX, to aid interpretation of structural …
The fifth edition of the WHO classification of mature B‐cell neoplasms: open questions for research
SE Coupland, MQ Du, JA Ferry… - The Journal of …, 2024 - Wiley Online Library
The fifth edition of the World Health Organization Classification of Haematolymphoid
Tumours (WHO‐HAEM5) is the product of an evidence‐based evolution of the revised fourth …
Tumours (WHO‐HAEM5) is the product of an evidence‐based evolution of the revised fourth …