Blood pressure management is a critical aspect of patient care, particularly in surgical and
critical care settings. Closed-loop systems, which utilize real-time data and feedback to …

Background Vasopressor agents are used to prevent intraoperative hypotension and ensure
adequate perfusion. Vasopressors are usually administered as intermittent boluses or …

Current trends in modern medicine are concerned with the development of the so-called
personalized medicine whose aim is tailoring of treatment to patients. The present research …

Introduction: Vasopressor infusions are essential in treating and preventing intraoperative
hypotension. Closed-loop vasopressor therapy outperforms clinicians when the target is set …

Background: Surgical interventions can cause severe fluid imbalances in patients
undergoing cardiac surgery, affecting length of hospital stay and survival. Therefore …

Purpose Ischemic myocardial contracture (IMC) or “stone heart” is a condition with rapid
onset following circulatory death. It inhibits transplantability of hearts donated upon …

The lack of methods to evaluate mechanical function of donated hearts in the context of
transplantation imposes large precautionary margins, translating into a low utilization rate of …

Ex vivo working porcine heart models allow for the study of a heart's function and physiology
outside the living organism. These models are particularly useful due to the anatomical and …

Introduction Intra-operative hypotension is a common complication of surgery under general
anesthesia in dogs and humans. Computer-controlled closed-loop infusion systems of …

Background Statistics indicate low utilization of potential donors, where only about one-third
are converted into actual donors. In this context, it is plausible to argue that many potential …