[HTML][HTML] Autoimmunity in centenarians. A paradox

JM Anaya, ID Lozada-Martinez, I Torres… - Journal of Translational …, 2024 - Elsevier
Autoimmune diseases (ADs) are one of the groups of chronic illnesses that impose a
significant burden of disease and health costs worldwide. Age is a crucial risk factor for the …

Nanomaterials for the diagnosis and treatment of inflammatory arthritis

SM Hosseinikhah, M Barani, A Rahdar… - International Journal of …, 2021 - mdpi.com
Nanomaterials have received increasing attention due to their unique chemical and physical
properties for the treatment of rheumatoid arthritis (RA), the most common complex …

[HTML][HTML] Latent rheumatic, thyroid and phospholipid autoimmunity in hospitalized patients with COVID-19

JM Anaya, DM Monsalve, M Rojas, Y Rodríguez… - Journal of translational …, 2021 - Elsevier
Autoimmune responses mediated by autoantibodies have been observed in SARS-CoV-2
infection. Herein, we evaluate the presence of rheumatic, thyroid and phospholipid …

Prevalence of latent and overt polyautoimmunity in autoimmune thyroid disease: A systematic review and meta‐analysis

A Botello, M Herrán, V Salcedo… - Clinical …, 2020 - Wiley Online Library
Background Thyroid autoimmunity is the most frequent condition involved in
polyautoimmunity (PolyA). However, the frequency of latent and overt PolyA in patients with …

ARID3a from the ARID family: structure, role in autoimmune diseases and drug discovery

C Guo, HE Xu, X Ma - Acta Pharmacologica Sinica, 2023 - nature.com
The AT-rich interaction domain (ARID) family of DNA-binding proteins is a group of
transcription factors and chromatin regulators with a highly conserved ARID domain that …

[HTML][HTML] New insights into the taxonomy of autoimmune diseases based on polyautoimmunity

M Rojas, C Ramírez-Santana, Y Acosta-Ampudia… - Journal of …, 2022 - Elsevier
Objective The clinical coexistence of two or more autoimmune diseases (ADs) fulfilling
classification criteria is termed “overt polyautoimmunity”(PolyA), whereas the presence of …

Polygenic autoimmune disease risk alleles impacting B cell tolerance act in concert across shared molecular networks in mouse and in humans

ITW Harley, K Allison, RH Scofield - Frontiers in immunology, 2022 - frontiersin.org
Most B cells produced in the bone marrow have some level of autoreactivity. Despite efforts
of central tolerance to eliminate these cells, many escape to periphery, where in healthy …

Unsupervised clustering reveals sarcoidosis phenotypes marked by a reduction in lymphocytes relate to increased inflammatory activity on 18FDG-PET/CT

C Vagts, C Ascoli, DR Fraidenburg… - Frontiers in …, 2021 - frontiersin.org
Introduction: Sarcoidosis is a T-helper cell mediated disease characterized by
granulomatous inflammation. We posited that unsupervised clustering of various features in …

The basics of data, big data, and machine learning in clinical practice

D Soriano-Valdez, I Pelaez-Ballestas… - Clinical …, 2021 - Springer
Health informatics and biomedical computing have introduced the use of computer methods
to analyze clinical information and provide tools to assist clinicians during the diagnosis and …

JAK inhibition decreases the autoimmune burden in Down syndrome

AL Rachubinski, E Wallace, E Gurnee, BAE Estrada… - MedRxiv, 2024 - pmc.ncbi.nlm.nih.gov
Individuals with Down syndrome (DS), the genetic condition caused by trisomy 21 (T21),
display clear signs of immune dysregulation, including high rates of autoimmune disorders …