Photodynamic Therapy for the Treatment and Diagnosis of Cancer–A Review of the Current Clinical Status

G Gunaydin, ME Gedik, S Ayan - Frontiers in chemistry, 2021 - frontiersin.org
Photodynamic therapy (PDT) has been used as an anti-tumor treatment method for a long
time and photosensitizers (PS) can be used in various types of tumors. Originally, light is an …

The roles of autophagy in cancer

CW Yun, SH Lee - International journal of molecular sciences, 2018 - mdpi.com
Autophagy is an intracellular degradative process that occurs under several stressful
conditions, including organelle damage, the presence of abnormal proteins, and nutrient …

Cancer stem cells and chemoresistance: The smartest survives the raid

J Zhao - Pharmacology & therapeutics, 2016 - Elsevier
Chemoresistant metastatic relapse of minimal residual disease plays a significant role for
poor prognosis of cancer. Growing evidence supports a critical role of cancer stem cell …

Cancer stem cell quiescence and plasticity as major challenges in cancer therapy

W Chen, J Dong, J Haiech, MC Kilhoffer… - Stem cells …, 2016 - Wiley Online Library
Cells with stem‐like properties, tumorigenic potential, and treatment‐resistant phenotypes
have been identified in many human malignancies. Based on the properties they share with …

Cancer stem cells (CSCs): metabolic strategies for their identification and eradication

EM De Francesco, F Sotgia, MP Lisanti - Biochemical Journal, 2018 - portlandpress.com
Phenotypic and functional heterogeneity is one of the most relevant features of cancer cells
within different tumor types and is responsible for treatment failure. Cancer stem cells …

Dissecting tumor growth: the role of cancer stem cells in drug resistance and recurrence

B Aramini, V Masciale, G Grisendi, F Bertolini, M Maur… - Cancers, 2022 - mdpi.com
Simple Summary Cancer is one of the most debated problems all over the world. Cancer
stem cells are considered responsible of tumor initiation, metastasis, drug resistance, and …

Therapeutic strategies targeting cancer stem cells

GJ Yoshida, H Saya - Cancer science, 2016 - Wiley Online Library
Cancer stem cells (CSC s) are undifferentiated cancer cells with a high tumorigenic activity,
the ability to undergo self‐renewal, and a multilineage differentiation potential. Cancer stem …

Vasculogenic mimicry signaling revisited: focus on non-vascular VE-cadherin

D Delgado-Bellido, S Serrano-Saenz… - Molecular cancer, 2017 - Springer
Vasculogenic mimicry (VM) is a blood supply system independent of endothelial vessels in
tumor cells from different origins. It reflects the plasticity of aggressive tumor cells that …

Progress in the development of small molecular inhibitors of focal adhesion kinase (FAK)

Y Lu, H Sun - Journal of Medicinal Chemistry, 2020 - ACS Publications
Focal adhesion kinase (FAK) is a nonreceptor intracellular tyrosine kinase that plays an
essential role in cancer cell adhesion, survival, proliferation, and migration through both its …

Exosomes in the tumor microenvironment: From biology to clinical applications

VR da Costa, RP Araldi, H Vigerelli, F D'Ámelio… - Cells, 2021 - mdpi.com
Cancer is one of the most important health problems and the second leading cause of death
worldwide. Despite the advances in oncology, cancer heterogeneity remains challenging to …