The rapid emergence of antifungal-resistant human-pathogenic fungi

SR Lockhart, A Chowdhary, JAW Gold - Nature Reviews Microbiology, 2023 - nature.com
During recent decades, the emergence of pathogenic fungi has posed an increasing public
health threat, particularly given the limited number of antifungal drugs available to treat …

The emergence and worldwide spread of the species Trichophyton indotineae causing difficult-to-treat dermatophytosis: A new challenge in the management of …

A Chowdhary, A Singh, A Kaur, A Khurana - PLoS Pathogens, 2022 - journals.plos.org
Superficial fungal infections of the skin, hair, and nails are the fourth most common cause of
human disease affecting 20% to 25% of the world's population [1]. Dermatophytosis is a …

[HTML][HTML] Extensive dermatophytosis caused by terbinafine-resistant Trichophyton indotineae, France

A Jabet, S Brun, AC Normand, S Imbert… - Emerging Infectious …, 2022 - ncbi.nlm.nih.gov
Extensive dermatophytosis caused by terbinafine-resistant Trichophyton indotineae
harboring Phe397Leu and Leu393Ser substitutions in the squalene epoxidase enzyme was …

Alarming India‐wide phenomenon of antifungal resistance in dermatophytes: a multicentre study

A Ebert, M Monod, K Salamin, A Burmester, S Uhrlaß… - Mycoses, 2020 - Wiley Online Library
Background An alarming increase in recalcitrant dermatophytosis has been witnessed in
India over the past decade. Drug resistance may play a major role in this scenario …

The current Indian epidemic of superficial dermatophytosis due to Trichophyton mentagrophytes—A molecular study

P Nenoff, SB Verma, R Vasani, A Burmester… - Mycoses, 2019 - Wiley Online Library
The disease burden of chronic‐relapsing and therapy‐refractory superficial dermatophytosis
dramatically increased in India within the past 5‐6 years. In order to evaluate the prevalence …

Terbinafine-resistant dermatophytes and the presence of Trichophyton indotineae in North America

CF Cañete-Gibas, J Mele, HP Patterson… - Journal of clinical …, 2023 - Am Soc Microbiol
Dermatophytes are common causes of skin, hair, and nail infections in humans. The most
common species causing infections in humans are Trichophyton rubrum, Trichophyton …

Antifungal resistance in dermatophytes: Recent trends and therapeutic implications

A Khurana, K Sardana, A Chowdhary - Fungal Genetics and Biology, 2019 - Elsevier
Dermatophytoses or tinea refers to superficial fungal infection of keratinized tissues.
Although generally considered easy to treat, recalcitrant infections, presenting as extensive …

Spread of Terbinafine-Resistant Trichophyton mentagrophytes Type VIII (India) in Germany–“The Tip of the Iceberg?”

P Nenoff, SB Verma, A Ebert, A Süß, E Fischer… - Journal of Fungi, 2020 - mdpi.com
Chronic recalcitrant dermatophytoses, due to Trichophyton (T.) mentagrophytes Type VIII are
on the rise in India and are noteworthy for their predominance. It would not be wrong to …

Antifungal resistance in dermatophytes: genetic considerations, clinical presentations and alternative therapies

R Sacheli, MP Hayette - Journal of Fungi, 2021 - mdpi.com
Numerous reports describe the emergence of resistance in dermatophytes, especially in T.
rubrum and T. mentagrophytes/indotineae strains. We here present a review of the current …

Emerging Terbinafine Resistance in Trichophyton: Clinical Characteristics, Squalene Epoxidase Gene Mutations, and a Reliable EUCAST Method for Detection

DML Saunte, RK Hare, KM Jørgensen… - Antimicrobial agents …, 2019 - Am Soc Microbiol
In recent years, cases involving terbinafine-resistant Trichophyton isolates have been
reported increasingly, particularly in India. We present 14 cases of terbinafine treatment …