A comprehensive account on recent progress in pharmacological activities of benzimidazole derivatives
Nowadays, nitrogenous heterocyclic molecules have attracted a great deal of interest
among medicinal chemists. Among these potential heterocyclic drugs, benzimidazole …
among medicinal chemists. Among these potential heterocyclic drugs, benzimidazole …
Therapeutic evolution of benzimidazole derivatives in the last quinquennial period
Benzimidazole, a fused heterocycle bearing benzene and imidazole has gained
considerable attention in the field of contemporary medicinal chemistry. The moiety is of …
considerable attention in the field of contemporary medicinal chemistry. The moiety is of …
Synthesis of novel inhibitors of α-glucosidase based on the benzothiazole skeleton containing benzohydrazide moiety and their molecular docking studies
In an effort to design and synthesize a new class of α-glucosidase inhibitor, we synthesized
benzothiazole hybrid having benzohydrazide moiety (5). Compound 5 was reacted with …
benzothiazole hybrid having benzohydrazide moiety (5). Compound 5 was reacted with …
Synthesis, molecular docking, acetylcholinesterase and butyrylcholinesterase inhibitory potential of thiazole analogs as new inhibitors for Alzheimer disease
A series of thirty (30) thiazole analogs were prepared, characterized by 1 H NMR, 13 C NMR
and EI-MS and evaluated for Acetylcholinesterase and butyrylcholinesterase inhibitory …
and EI-MS and evaluated for Acetylcholinesterase and butyrylcholinesterase inhibitory …
Synthesis of novel flavone hydrazones: In-vitro evaluation of α-glucosidase inhibition, QSAR analysis and docking studies
Thirty derivatives of flavone hydrazone (5–34) had been synthesized through a five-step
reaction and screened for their α-glucosidase inhibition activity. Chalcone 1 was …
reaction and screened for their α-glucosidase inhibition activity. Chalcone 1 was …
Synthesis, in vitro evaluation and molecular docking studies of thiazole derivatives as new inhibitors of α-glucosidase
A series of thiazole derivatives 1–21 were prepared, characterized by EI-MS and 1 H NMR
and evaluated for α-glucosidase inhibitory potential. All twenty one derivatives showed good …
and evaluated for α-glucosidase inhibitory potential. All twenty one derivatives showed good …
Triazinoindole analogs as potent inhibitors of α-glucosidase: Synthesis, biological evaluation and molecular docking studies
A new series of triazinoindole analogs 1–11 were synthesized, characterized by EI-MS and
1 H NMR, evaluated for α-glucosidase inhibitory potential. All eleven (11) analogs showed …
1 H NMR, evaluated for α-glucosidase inhibitory potential. All eleven (11) analogs showed …
Synthesis, in vitro alpha-glucosidase inhibitory potential of benzimidazole bearing bis-Schiff bases and their molecular docking study
Voglibose and acarbose are distinguished α-glucosidase inhibitors used for controlling of
diabetes mellitus. Unfortunately, these distinguished and clinically used inhibitors have also …
diabetes mellitus. Unfortunately, these distinguished and clinically used inhibitors have also …
Benzimidazole derivatives as new α-glucosidase inhibitors and in silico studies
Newly synthesized benzimidazole hydrazone derivatives 1–26 were evaluated for their α-
glucosidase inhibitory activity. Compounds 1–26 exhibited varying degrees of yeast α …
glucosidase inhibitory activity. Compounds 1–26 exhibited varying degrees of yeast α …
Design, molecular docking and synthesis of novel 5, 6-dichloro-2-methyl-1H-benzimidazole derivatives as potential urease enzyme inhibitors
Abstract A novel series of 5, 6-dichloro-2-methyl-1H-benzimidazole derivatives was
synthesized and then screened for their urease inhibitory activity. All compounds showed …
synthesized and then screened for their urease inhibitory activity. All compounds showed …