Lipid composition determines membrane properties, and cholesterol plays a major role in
this determination as it regulates membrane fluidity and permeability, as well as induces the …

Since its inception more than thirty years ago, electroformation has become the most
commonly used method for growing giant unilamellar vesicles (GUVs). Although the method …

Cholesterol (Chol) is an essential component of animal cell membranes and is most
abundant in plasma membranes (PMs) where its concentration typically ranges from 10 to …

Giant unilamellar vesicles (GUVs) are artificial membrane models which are of special
interest to researchers because of their similarity in size to eukaryotic cells. The most …

Purpose: This research was undertaken to document the changes in the organization and
properties of human lens lipid membranes that occur with age. Methods: Human lens lipid …

Cholesterol (Chol) content in most cellular membranes does not exceed 50 mol%, only in
the eye lens's fiber cell plasma membrane, its content surpasses 50 mol%. At this high …

α-crystallin is a major protein found in the mammalian eye lens that works as a molecular
chaperone by preventing the aggregation of proteins and providing tolerance to stress in the …

Artificial vesicles are important tools in membrane research because they enable studying
membrane properties in controlled conditions. Giant unilamellar vesicles (GUVs) are …

The most unique biochemical characteristic of the eye lens fiber cell plasma membrane is its
extremely high cholesterol content, the need for which is still unclear. It is evident, however …

The plasma membranes of the human lens fiber cell are overloaded with cholesterol that not
only saturates the phospholipid bilayer of these membranes but also leads to the formation …