Pathogenic antibiotic resistant bacteria pose one of the most important health challenges of
the 21st century. The overuse and abuse of antibiotics coupled with the natural evolutionary …

Actinomycetes are regarded as important sources for the generation of various bioactive
secondary metabolites with rich chemical and bioactive diversities. Amycolatopsis falls …

Summary Since 1967, Rifampin (RMP, a Rifamycin) has been used as a first line antibiotic
treatment for tuberculosis (TB), and it remains the cornerstone of current short‐term TB …

Phenotypic screens for bactericidal compounds are starting to yield promising hits against
tuberculosis. In this regard, whole-genome sequencing of spontaneous resistant mutants …

Acyltransferase (AT) domains of polyketide synthases (PKSs) select extender units for
incorporation into polyketides and dictate large portions of the structures of clinically relevant …

Covering: 2011 to 2021 Structural division of natural naphthalenoid ansamycins, regarding
the type of the core and length of the ansa chain, and their biosynthetic pathways in …

The draft genome sequence of an agriculturally important actinobacterial species
Amycolatopsis sp. BCA-696 was developed and characterized in this study. Amycolatopsis …

RNA polymerases (RNAPs) accomplish the first step of gene expression in all living
organisms. However, the sequence divergence between bacterial and human RNAPs …

Rifampicin (Rif) is a first line drug used for tuberculosis treatment. However, the emergence
of drug resistant strains has necessitated synthesis and testing of newer analogs of Rif …

The emergence of antibiotic-resistant pathogenic bacteria in recent decades leads us to an
urgent need for the development of new antibacterial agents. The species of the genus …