Promises and challenges of cell-based therapies to promote lung regeneration in idiopathic pulmonary fibrosis
The lung epithelium is constantly exposed to harmful agents present in the air that we
breathe making it highly susceptible to damage. However, in instances of injury to the lung, it …
breathe making it highly susceptible to damage. However, in instances of injury to the lung, it …
The journey towards clinical adoption of MALDI‐MS‐based imaging proteomics: from current challenges to future expectations
Among the spatial omics techniques available, mass spectrometry imaging (MSI) represents
one of the most promising owing to its capability to map the distribution of hundreds of …
one of the most promising owing to its capability to map the distribution of hundreds of …
Spatial and phenotypic heterogeneity of resident and monocyte-derived macrophages during inflammatory exacerbations leading to pulmonary fibrosis
PJ Moos, JR Cheminant, S Cowman, J Noll… - Frontiers in …, 2024 - frontiersin.org
Introduction Genetic mutations in critical nodes of pulmonary epithelial function are linked to
the pathogenesis of pulmonary fibrosis (PF) and other interstitial lung diseases. The slow …
the pathogenesis of pulmonary fibrosis (PF) and other interstitial lung diseases. The slow …
Proteomic fingerprint of lung fibrosis progression and response to therapy in bleomycin-induced mouse model
L Principi, E Ferrini, R Ciccimarra, L Pagani… - International journal of …, 2023 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterized by the aberrant
accumulation of extracellular matrix in the lungs. nintedanib is one of the two FDA-approved …
accumulation of extracellular matrix in the lungs. nintedanib is one of the two FDA-approved …
A fully automated micro‑CT deep learning approach for precision preclinical investigation of lung fibrosis progression and response to therapy
M Buccardi, E Ferrini, F Pennati, E Vincenzi… - Respiratory …, 2023 - Springer
Micro-computed tomography (µCT)-based imaging plays a key role in monitoring disease
progression and response to candidate drugs in various animal models of human disease …
progression and response to candidate drugs in various animal models of human disease …
Indocyanine-enhanced mouse model of bleomycin-induced lung fibrosis with hallmarks of progressive emphysema
A Grandi, E Ferrini, L Mecozzi… - … of Physiology-Lung …, 2023 - journals.physiology.org
The development of new drugs for idiopathic pulmonary fibrosis strongly relies on preclinical
experimentation, which requires the continuous improvement of animal models and …
experimentation, which requires the continuous improvement of animal models and …
Quantitative multiplex immunohistochemistry with colorimetric staining (QUIVER) may still benefit from MILAN
Cyclic multiplex immunostaining consists of cycles of staining, imaging, removal of the signal
and repetition with another set of antibodies. Removal of the primary and secondary …
and repetition with another set of antibodies. Removal of the primary and secondary …
Recent Developments in High Spatio-Temporal Image-Based Tracking of Proteins in Subcellular Spatial Proteomics Applications
W Ng - 2023 - preprints.org
Dawn of the omics revolution in biological sciences meant that we seek to understand more
and in greater detail the molecular constituents of cells and biological systems. While we …
and in greater detail the molecular constituents of cells and biological systems. While we …