How to score sedation and adjust the administration rate of sedatives in horses: a literature review and introduction of the Ghent Sedation Algorithm
S Schauvliege, C Cuypers, A Michielsen… - Veterinary anaesthesia …, 2019 - Elsevier
Objective To summarize the different methods used to assess sedation and/or adjust the
dose or administration rate of alpha-2 agonists in horses and to propose an algorithm to …
dose or administration rate of alpha-2 agonists in horses and to propose an algorithm to …
Therapeutic developments in equine pain management
KR Mama, RC Hector - The Veterinary Journal, 2019 - Elsevier
Many drugs and non-drug modalities are used to manage pain in horses, but evidence
regarding efficacy and safety remains limited. This manuscript will first briefly review tried …
regarding efficacy and safety remains limited. This manuscript will first briefly review tried …
[HTML][HTML] Effect of constant rate infusion of detomidine with and without vatinoxan on blood glucose and insulin concentrations in horses
I Hallman, H Tapio, M Raekallio, N Karikoski - Veterinary Anaesthesia and …, 2024 - Elsevier
Objective To assess the effects of an α 2-adrenoceptor agonist (detomidine) constant rate
infusion (CRI) with and without an α 2-adrenoceptor antagonist (vatinoxan) CRI on blood …
infusion (CRI) with and without an α 2-adrenoceptor antagonist (vatinoxan) CRI on blood …
Concentrations of medetomidine enantiomers and vatinoxan, an α2-adrenoceptor antagonist, in plasma and central nervous tissue after intravenous coadministration …
JM Honkavaara, MR Raekallio, PM Syrja… - Veterinary anaesthesia …, 2020 - Elsevier
Objective To quantify the peripheral selectivity of vatinoxan (L-659,066, MK-467) in dogs by
comparing the concentrations of vatinoxan, dexmedetomidine and levomedetomidine in …
comparing the concentrations of vatinoxan, dexmedetomidine and levomedetomidine in …
Effects of constant rate infusions of dexmedetomidine or MK-467 on the minimum alveolar concentration of sevoflurane in dogs
RC Hector, ML Rezende, KR Mama, EP Steffey… - Veterinary anaesthesia …, 2017 - Elsevier
Objective To determine the effects of low and high dose infusions of dexmedetomidine and a
peripheral α 2-adrenoceptor antagonist, MK-467, on sevoflurane minimum alveolar …
peripheral α 2-adrenoceptor antagonist, MK-467, on sevoflurane minimum alveolar …
The impact of MK-467 on sedation, heart rate and arterial blood pressure after intramuscular coadministration with dexmedetomidine in conscious cats
J Honkavaara, B Pypendop, J Ilkiw - Veterinary anaesthesia and analgesia, 2017 - Elsevier
Objective To study the effects of MK-467, a peripheral α 2-adrenoceptor antagonist, on
sedation, heart rate and blood pressure after intramuscular (IM) coadministration with 25 μg …
sedation, heart rate and blood pressure after intramuscular (IM) coadministration with 25 μg …
Effects of MK-467 hydrochloride and hyoscine butylbromide on cardiorespiratory and gastrointestinal changes induced by detomidine hydrochloride in horses
HA Tapio, MR Raekallio, A Mykkänen… - American journal of …, 2018 - Am Vet Med Assoc
OBJECTIVE To compare the effects of MK-467 and hyoscine butylbromide on detomidine
hydrochloride–induced cardiorespiratory and gastrointestinal changes in horses. ANIMALS …
hydrochloride–induced cardiorespiratory and gastrointestinal changes in horses. ANIMALS …
Effects of vatinoxan on cardiorespiratory function and gastrointestinal motility during constant‐rate medetomidine infusion in standing horses
H Tapio, MR Raekallio, A Mykkänen… - Equine veterinary …, 2019 - Wiley Online Library
Background Medetomidine suppresses cardiovascular function and reduces gastrointestinal
motility in horses mainly through peripheral α2‐adrenoceptors. Vatinoxan, a peripheral α2 …
motility in horses mainly through peripheral α2‐adrenoceptors. Vatinoxan, a peripheral α2 …
Effects of dexmedetomidine, with or without vatinoxan (MK-467), on minimum alveolar concentration of isoflurane in cats
BH Pypendop, H Ahokoivu, J Honkavaara - Veterinary anaesthesia and …, 2019 - Elsevier
Objective To characterize the effects of dexmedetomidine, with or without vatinoxan, on the
minimum alveolar concentration of isoflurane (MAC ISO) in cats. Study design Randomized …
minimum alveolar concentration of isoflurane (MAC ISO) in cats. Study design Randomized …
Effect of dexmedetomidine and xylazine followed by MK-467 on gastrointestinal microperfusion in anaesthetized horses
L Wittenberg-Voges, SBR Kästner, M Raekallio… - Veterinary anaesthesia …, 2018 - Elsevier
Objective To compare the effects of MK-467 during isoflurane anaesthesia combined with
xylazine or dexmedetomidine on global and gastrointestinal perfusion parameters. Study …
xylazine or dexmedetomidine on global and gastrointestinal perfusion parameters. Study …