The molecular components of the postsynaptic density (PSD) in excitatory synapses of the
brain are currently being investigated as one of the major etiologies of neurodevelopmental …

The introduction of high-resolution time lapse imaging and molecular biological tools has
changed dramatically the rate of progress towards the understanding of the complex …

Schizophrenia is a neurodevelopmental disorder whose clinical features include
impairments in perception, cognition and motivation. These impairments reflect alterations in …

Brain‐derived neurotrophic factor (BDNF) is a prototypic neurotrophin that regulates diverse
developmental events from the selection of neural progenitors to the terminal dendritic …

PDZ domains are protein-interaction domains that are often found in multi-domain
scaffolding proteins. PDZ-containing scaffolds assemble specific proteins into large …

Dendritic spines are tiny protrusions that receive excitatory synaptic input and
compartmentalize postsynaptic responses. Heterogeneous in size and shape, and …

Excitatory (glutamatergic) synapses in the mammalian brain are usually situated on dendritic
spines, a postsynaptic microcompartment that also harbors organelles involved in protein …

Rho GTPases control many aspects of cell behavior through the regulation of multiple signal
transduction pathways (Van Aelst and D'Souza-Schorey 1997; Hall 1998). Rho, Rac, and …

Our brain serves as a center for cognitive function and neurons within the brain relay and
store information about our surroundings and experiences. Modulation of this complex …

Summary SynGAP is a Ras-GTPase activating protein highly enriched at excitatory
synapses in the brain. Previous studies have shown that CaMKII and the RAS-ERK pathway …