Transposable elements and retroviruses are found in most genomes, can be pathogenic
and are widely used as gene-delivery and functional genomics tools. Exploring whether …

To complete its life cycle, HIV-1 enters the nucleus of the host cell as reverse-transcribed
viral DNA. The nucleus is a complex environment, in which chromatin is organized to …

Summary Human immunodeficiency virus (HIV-1) remains a major health threat. Viral capsid
uncoating and nuclear import of the viral genome are critical for productive infection. The …

HIV-1 replication commences inside the cone-shaped viral capsid, but timing, localization,
and mechanism of uncoating are under debate. We adapted a strategy to visualize …

HIV-1 integration into the host genome favors actively transcribed genes. Prior work
indicated that the nuclear periphery provides the architectural basis for integration site …

Nuclear entry of HIV-1 replication complexes through intact nuclear pore complexes is
critical for successful infection. The host protein cleavage-and-polyadenylation-specificity …

The HIV-1 core consists of capsid proteins (CA) surrounding viral genomic RNA. After virus-
cell fusion, the core enters the cytoplasm and the capsid shell is lost through uncoating. CA …

Treatment with antiretroviral therapy dramatically increases the survival of HIV-infected
individuals. However, treatment has to be continued for life because it does not lead to the …

Human immunodeficiency virus (HIV) infection is currently incurable, due to the persistence
of latently infected cells. The 'shock and kill'approach to a cure proposes to eliminate this …

The RNA genome of human immunodeficiency virus type 1 (HIV-1) is enclosed by a capsid
shell that dissociates within the cell in a multistep process known as uncoating, which …