G‐protein–coupled receptor (GPCR) signaling is essential for the spatiotemporal control of
leukocyte dynamics during immune responses. For efficient navigation through mammalian …

Chemotaxis, where cell movement is steered by chemical gradients, is a widespread and
essential way of organising cell behaviour. But where do the instructions come from–who …

The physical microenvironment of tumours is characterized by heterotypic cell interactions
and physiological gradients of nutrients, waste products and oxygen. This tumour …

Electric fields are generated in vivo in a variety of physiologic and pathologic settings,
including wound healing and immune response to injuries to epithelial barriers (eg lung …

Establishing cell migration assays in multiple different microenvironments is important in the
study of tissue repair and regeneration, cancer progression, atherosclerosis, and arthritis. In …

Neutrophil chemotaxis plays a vital role in human immune system. Compared with
traditional cell migration assays, the emergence of microfluidics provides a new research …

Neutrophils are the first responders to infection and play a pivotal role in many inflammatory
diseases, including sepsis. Recent studies have shown that lipopolysaccharide (LPS), a …

Inflammation is an indispensable component of the immune response, and leukocytes
provide the first line of defense against infection. Although the major stereotypic leukocyte …

A simple microfluidic valve, without any moving parts, is presented that can control solution
flow on demand in microchannels of many different materials using a low‐power electric …

Concentration gradients of biochemical stimuli such as morphogens play a critical role in
directing cell fate patterning across species and throughout development but are not …