Biomaterials: foreign bodies or tuners for the immune response?

E Mariani, G Lisignoli, RM Borzì… - International journal of …, 2019 - mdpi.com
The perspectives of regenerative medicine are still severely hampered by the host response
to biomaterial implantation, despite the robustness of technologies that hold the promise to …

[HTML][HTML] From properties to toxicity: Comparing microplastics to other airborne microparticles

S Wieland, A Balmes, J Bender, J Kitzinger… - Journal of Hazardous …, 2022 - Elsevier
Microplastic (MP) debris is considered as a potentially hazardous material. It is omnipresent
in our environment, and evidence that MP is also abundant in the atmosphere is increasing …

Domesticating the foreign body response: Recent advances and applications

O Veiseh, AJ Vegas - Advanced drug delivery reviews, 2019 - Elsevier
The foreign body response is an immunological process that leads to the rejection of
implanted devices and presents a fundamental challenge to their performance, durability …

The role of biomaterials and scaffolds in immune responses in regenerative medicine: macrophage phenotype modulation by biomaterial properties and scaffold …

E Antmen, NE Vrana, V Hasirci - Biomaterials science, 2021 - pubs.rsc.org
Scaffolds are an integral part of the regenerative medicine field. The contact of biomaterials
with tissue, as was clearly observed over the years, induces immune reactions in a material …

Designing biomaterials with immunomodulatory properties for tissue engineering and regenerative medicine

JI Andorko, CM Jewell - Bioengineering & translational …, 2017 - Wiley Online Library
Recent research in the vaccine and immunotherapy fields has revealed that biomaterials
have the ability to activate immune pathways, even in the absence of other immune …

Nanosensor detection of reactive oxygen and nitrogen species leakage in frustrated phagocytosis of nanofibres

YT Qi, FL Zhang, SY Tian, HQ Wu, Y Zhao… - Nature …, 2024 - nature.com
Exposure to widely used inert fibrous nanomaterials (for example, glass fibres or carbon
nanotubes) may result in asbestos-like lung pathologies, becoming an important …

Adverse outcome pathways as a tool for the design of testing strategies to support the safety assessment of emerging advanced materials at the nanoscale

S Halappanavar, S Van Den Brule, P Nymark… - Particle and Fibre …, 2020 - Springer
Toxicity testing and regulation of advanced materials at the nanoscale, ie nanosafety, is
challenged by the growing number of nanomaterials and their property variants requiring …

Advanced strategies for modulation of the material–macrophage interface

L Davenport Huyer, S Pascual‐Gil… - Advanced Functional …, 2020 - Wiley Online Library
Biomaterials are becoming increasingly crucial for healthcare solutions, with extensive use
in the field of tissue engineering and drug delivery. After implantation, biomaterials trigger an …

Differentially Induced Autophagy by Engineered Nanomaterial Treatment Has an Impact on Cellular Homeostasis and Cytotoxicity

V Alcolea-Rodriguez, VI Dumit, R Ledwith… - Nano Letters, 2024 - ACS Publications
Considering the increasing production of engineered nanomaterials (ENMs), new approach
methodologies (NAMs) are essential for safe-by-design approaches and risk assessment …

The immune microenvironment in mesothelioma: mechanisms of resistance to immunotherapy

GJ Chu, N Van Zandwijk, JEJ Rasko - Frontiers in Oncology, 2019 - frontiersin.org
Although mesothelioma is the consequence of a protracted immune response to asbestos
fibers and characterized by a clear immune infiltrate, novel immunotherapy approaches …