Perineuronal nets (PNNs) are extracellular matrix (ECM) chondroitin sulfate proteoglycan
(CSPG)-containing structures that surround the soma and dendrites of various mammalian …

A perineuronal net (PNN) is a layer of lattice‐like matrix which enwraps the surface of the
soma and dendrites, and in some cases the axon initial segments, in sub‐populations of …

Background Perineuronal nets (PNNs) are extracellular matrix structures that enwrap many
neurons in the brain. They regulate the postnatal experience-dependent maturation of brain …

A hypothesis and the experiments to test it propose that very long-term memories, such as
fear conditioning, are stored as the pattern of holes in the perineuronal net (PNN), a …

Lysosomes have traditionally been viewed as degradative organelles, although a growing
body of evidence suggests that they can function as Ca 2+ stores. Here we examined the …

Abnormal sensory responses associated with Fragile X Syndrome (FXS) and autism
spectrum disorders include hypersensitivity and impaired habituation to repeated stimuli …

CD44 is the major surface hyaluronan (HA) receptor implicated in intercellular and cell-
matrix adhesion, cell migration and signaling. It is a transmembrane, highly glycosylated …

Rewiring of synaptic circuitry pertinent to memory formation has been associated with
morphological changes in dendritic spines and with extracellular matrix (ECM) remodeling …

Alzheimer's disease is the most prevalent tauopathy and cause of dementia. We investigate
the hypothesis that reactivation of plasticity can restore function in the presence of neuronal …

Fmr1 knock-out (ko) mice display key features of fragile X syndrome (FXS), including
delayed dendritic spine maturation and FXS-associated behaviors, such as poor …