Recent development in indole derivatives as anticancer agent: A mechanistic approach
N Devi, K Kaur, A Biharee… - Anti-Cancer Agents in …, 2021 - ingentaconnect.com
Background: Cancer accounts for several deaths each year. There are multiple FDA
approved drugs for cancer treatments. Due to the severe side effects and multiple drug …
approved drugs for cancer treatments. Due to the severe side effects and multiple drug …
A survey on the synthesis of variolins, meridianins, and meriolins—naturally occurring marine (aza) indole alkaloids and their semisynthetic derivatives
M Kruppa, TJJ Müller - Molecules, 2023 - mdpi.com
Marine natural products are a source of essential significance due to a plethora of highly
diverse biological properties. The naturally occurring (aza) indole alkaloids variolin B (1) …
diverse biological properties. The naturally occurring (aza) indole alkaloids variolin B (1) …
Novel meriolin derivatives activate the mitochondrial apoptosis pathway in the presence of antiapoptotic Bcl-2
L Schmitt, I Lechtenberg, D Drießen… - Cell Death …, 2024 - nature.com
Meriolin derivatives represent a new class of kinase inhibitors with a pronounced cytotoxic
potential. Here, we investigated a newly synthesized meriolin derivative (termed meriolin 16) …
potential. Here, we investigated a newly synthesized meriolin derivative (termed meriolin 16) …
Novel meriolin derivatives potently inhibit cell cycle progression and transcription in leukemia and lymphoma cells via inhibition of cyclin-dependent kinases (CDKs)
L Schmitt, J Hoppe, P Cea-Medina, PM Bruch… - Cell Death …, 2024 - nature.com
A key feature of cancer is the disruption of cell cycle regulation, which is characterized by the
selective and abnormal activation of cyclin-dependent kinases (CDKs). Consequently …
selective and abnormal activation of cyclin-dependent kinases (CDKs). Consequently …
A systematic review on understanding the mechanistic pathways and clinical aspects of natural CDK inhibitors on cancer progression.: Unlocking cellular and …
Cell division, differentiation, and controlled cell death are all regulated by phosphorylation, a
key biological function. This mechanism is controlled by a variety of enzymes, with cyclin …
key biological function. This mechanism is controlled by a variety of enzymes, with cyclin …
[HTML][HTML] Novel 4-alkoxy Meriolin Congeners Potently Induce Apoptosis in Leukemia and Lymphoma Cells
KS Krings, TR Wassenberg, P Cea-Medina, L Schmitt… - Molecules, 2024 - mdpi.com
Meriolins (3-(pyrimidin-4-yl)-7-azaindoles) are synthetic hybrids of the naturally occurring
alkaloids variolin and meridianin and display a strong cytotoxic potential. We have recently …
alkaloids variolin and meridianin and display a strong cytotoxic potential. We have recently …
Novel meriolin derivatives potently inhibit cell cycle progression and transcription in leukemia and lymphoma cells via inhibition of cyclin-dependent kinases (CDKs)
S Wesselborg, L Schmitt, J Hoppe, P Cea-Medina… - 2024 - researchsquare.com
A fundamental aspect of cancer is the dysregulation of cell cycle control, which is associated
with selective, aberrant activation of cyclin-dependent kinases (CDK). Consequently …
with selective, aberrant activation of cyclin-dependent kinases (CDK). Consequently …
Novel meriolin derivatives activate the mitochondrial apoptosis pathway in the presence of antiapoptotic Bcl-2
S Wesselborg, L Schmitt, I Hinxlage, D Drießen… - 2023 - researchsquare.com
Meriolin derivatives represent a new class of kinase inhibitors with a pronounced cytotoxic
potential. Here, we investigated a newly synthesized meriolin derivative (termed meriolin 16) …
potential. Here, we investigated a newly synthesized meriolin derivative (termed meriolin 16) …