Antimicrobial drug resistance is a growing threat to global public health. Multidrug resistance
among the'ESKAPE'organisms—encompassing Enterococcus faecium, Staphylococcus …

Trehalose is a disaccharide of two D-glucose molecules linked by a glycosidic linkage,
which plays both structural and functional roles in bacteria. Trehalose can be synthesized …

Essential genes refer to genes that are required by an organism to survive under specific
conditions. Studies of the minimal-gene-set for bacteria have elucidated fundamental …

Defining the essential genome of bacterial pathogens is central to developing an
understanding of the biological processes controlling disease. This has proven elusive for …

Giant viruses (GVs) are a hotspot of unresolved controversies since their discovery,
including the definition of “Virus” and their origin. While increasing knowledge of genome …

Clostridium difficile is the most common cause of antibiotic-associated intestinal infections
and a significant cause of morbidity and mortality. Infection with C. difficile requires …

The soil saprophyte, Burkholderia pseudomallei, is the causative agent of melioidosis, a
disease endemic in South East Asia and northern Australia. Exposure to B. pseudomallei by …

Abstract Streptococcus pyogenes (Group A Streptococcus, GAS) remains a major public
health burden worldwide, infecting over 750 million people leading to over 500,000 deaths …

Introduction: The development of new antimicrobials has become an urgent priority because
of a global challenge emerging from the rise of antimicrobial resistant pathogens. Areas …

Klebsiella pneumoniae causes severe lung and bloodstream infections that are difficult to
treat due to multidrug resistance. We hypothesized that antimicrobial resistance can be …