Circadian rhythms and cancers: the intrinsic links and therapeutic potentials

L Zhou, Z Zhang, E Nice, C Huang, W Zhang… - Journal of Hematology & …, 2022 - Springer
The circadian rhythm is an evolutionarily conserved time-keeping system that comprises a
wide variety of processes including sleep–wake cycles, eating–fasting cycles, and activity …

Circadian rhythm and disease: Relationship, new insights, and future perspectives

AR Neves, T Albuquerque, T Quintela… - Journal of cellular …, 2022 - Wiley Online Library
The circadian system is responsible for internal functions and regulation of the organism
according to environmental cues (zeitgebers). Circadian rhythm dysregulation or …

Nucleotide excision repair in Human cell lines lacking both XPC and CSB proteins

LA Lindsey-Boltz, Y Yang, C Kose… - Nucleic Acids …, 2023 - academic.oup.com
Nucleotide excision repair removes UV-induced DNA damage through two distinct sub-
pathways, global repair and transcription-coupled repair (TCR). Numerous studies have …

[HTML][HTML] Interactions of circadian clock genes with the hallmarks of cancer

SM Ortega-Campos, EM Verdugo-Sivianes… - … et Biophysica Acta (BBA …, 2023 - Elsevier
The molecular machinery of the circadian clock regulates the expression of many genes and
processes in the organism, allowing the adaptation of cellular activities to the daily light-dark …

Obesity, cancer risk, and time-restricted eating

M Das, NJG Webster - Cancer and Metastasis Reviews, 2022 - Springer
Obesity and the associated metabolic syndrome is considered a pandemic whose
prevalence is steadily increasing in many countries worldwide. It is a complex, dynamic, and …

[HTML][HTML] Circadian synchrony: sleep, nutrition, and physical activity

KL Healy, AR Morris, AC Liu - Frontiers in network physiology, 2021 - frontiersin.org
The circadian clock in mammals regulates the sleep/wake cycle and many associated
behavioral and physiological processes. The cellular clock mechanism involves a …

Recent advances in chronotherapy targeting respiratory diseases

KR Paudel, SK Jha, VSRR Allam, P Prasher, PK Gupta… - Pharmaceutics, 2021 - mdpi.com
Respiratory diseases contribute to a significant percentage of mortality and morbidity
worldwide. The circadian rhythm is a natural biological process where our bodily functions …

Circadian clock and lipid metabolism disorders: a potential therapeutic strategy for cancer

M Liu, Z Zhang, Y Chen, T Feng, Q Zhou… - Frontiers in …, 2023 - frontiersin.org
Recent research has emphasized the interaction between the circadian clock and lipid
metabolism, particularly in relation to tumors. This review aims to explore how the circadian …

Mutations of the circadian clock genes Cry, Per, or Bmal1 have different effects on the transcribed and nontranscribed strands of cycling genes

Y Yang, G Wu, A Sancar… - Proceedings of the …, 2024 - National Acad Sciences
One important goal of circadian medicine is to apply time-of-day dosing to improve the
efficacy of chemotherapy. However, limited knowledge of how the circadian clock regulates …

Role of the Circadian Gas-Responsive Hemeprotein NPAS2 in Physiology and Pathology

E Murgo, T Colangelo, MM Bellet, F Malatesta… - Biology, 2023 - mdpi.com
Simple Summary NPAS2, short for Neuronal PAS Domain Protein 2, is a transcription factor
involved in regulating the circadian rhythms and sleep–wake cycles in mammals, including …