The function of many biological systems, such as embryos, liver lobules, intestinal villi, and
tumors, depends on the spatial organization of their cells. In the past decade, high …

During pregnancy, the placenta forms the anatomical barrier between the mother and
developing fetus. Infectious agents can potentially breach the placental barrier resulting in …

Spatial transcriptomics technologies generate gene expression profiles with spatial context,
requiring spatially informed analysis tools for three key tasks, spatial clustering, multisample …

In the past decades, transcriptomic studies have revolutionized cancer treatment and
diagnosis. However, tumor sequencing strategies typically result in loss of spatial …

Recent development of spatial transcriptomic technologies has made it possible to
characterize cellular heterogeneity with spatial information. However, the technology often …

Charting an organs' biological atlas requires us to spatially resolve the entire single-cell
transcriptome, and to relate such cellular features to the anatomical scale. Single-cell and …

Single-cell RNA sequencing methods can profile the transcriptomes of single cells but
cannot preserve spatial information. Conversely, spatial transcriptomics assays can profile …

Formalin-fixed paraffin embedding (FFPE) is the most widespread long-term tissue
preservation approach. Here we present a procedure to perform genome-wide spatial …

Formalin-fixed paraffin embedding (FFPE) is the most widespread long-term tissue
preservation approach. Here, we report a procedure to perform genome-wide spatial …

In recent years, the emergence of single‐cell omics technologies, which can profile
genomics, transcriptomics, epigenomics, and proteomics, has provided unprecedented …