Paramagnetic chemical probes for studying biological macromolecules
Paramagnetic chemical probes have been used in electron paramagnetic resonance (EPR)
and nuclear magnetic resonance (NMR) spectroscopy for more than four decades. Recent …
and nuclear magnetic resonance (NMR) spectroscopy for more than four decades. Recent …
Investigating protein–ligand interactions by solution nuclear magnetic resonance spectroscopy
W Becker, KC Bhattiprolu, N Gubensäk… - …, 2018 - Wiley Online Library
Protein–ligand interactions are of fundamental importance in almost all processes in living
organisms. The ligands comprise small molecules, drugs or biological macromolecules and …
organisms. The ligands comprise small molecules, drugs or biological macromolecules and …
Structure and inhibition of the SARS coronavirus envelope protein ion channel
K Pervushin, E Tan, K Parthasarathy, X Lin… - PLoS …, 2009 - journals.plos.org
The envelope (E) protein from coronaviruses is a small polypeptide that contains at least
one α-helical transmembrane domain. Absence, or inactivation, of E protein results in …
one α-helical transmembrane domain. Absence, or inactivation, of E protein results in …
NMR approaches for structural analysis of multidomain proteins and complexes in solution
NMR spectroscopy is a key method for studying the structure and dynamics of (large)
multidomain proteins and complexes in solution. It plays a unique role in integrated …
multidomain proteins and complexes in solution. It plays a unique role in integrated …
[HTML][HTML] Simplifying proton NMR spectra by instant homonuclear broadband decoupling
NMR spectroscopy is a versatile tool to determine structural, chemical, and physical
properties of molecules. One-dimensional 1H NMR spectra probably represent the most …
properties of molecules. One-dimensional 1H NMR spectra probably represent the most …
Expanding the utility of NMR restraints with paramagnetic compounds: background and practical aspects
NMR spectroscopy is one of the most important methods for determining protein structures.
The scientific community is constantly pushing the limits of NMR spectroscopy by …
The scientific community is constantly pushing the limits of NMR spectroscopy by …
[HTML][HTML] Hsp12 is an intrinsically unstructured stress protein that folds upon membrane association and modulates membrane function
S Welker, B Rudolph, E Frenzel, F Hagn, G Liebisch… - Molecular cell, 2010 - cell.com
Hsp12 of S. cerevisiae is upregulated several 100-fold in response to stress. Our phenotypic
analysis showed that this protein is important for survival of a variety of stress conditions …
analysis showed that this protein is important for survival of a variety of stress conditions …
A novel chimeric cell-penetrating peptide with membrane-disruptive properties for efficient endosomal escape
Efficient endocytosis into a wide range of target cells and low toxicity make the arginine-rich
Tat peptide (Tat11: YGRKKRRQRRR, residues 47–57 of HIV-1 Tat protein) an excellent …
Tat peptide (Tat11: YGRKKRRQRRR, residues 47–57 of HIV-1 Tat protein) an excellent …
[HTML][HTML] Solution NMR studies of amphibian antimicrobial peptides: linking structure to function?
The high-resolution three-dimensional structure of an antimicrobial peptide has implications
for the mechanism of its antimicrobial activity, as the conformation of the peptide provides …
for the mechanism of its antimicrobial activity, as the conformation of the peptide provides …
Mechanism of inhibition of enveloped virus membrane fusion by the antiviral drug arbidol
E Teissier, G Zandomeneghi, A Loquet, D Lavillette… - PloS one, 2011 - journals.plos.org
The broad-spectrum antiviral arbidol (Arb) inhibits cell entry of enveloped viruses by
blocking viral fusion with host cell membrane. To better understand Arb mechanism of …
blocking viral fusion with host cell membrane. To better understand Arb mechanism of …