This review provides a summary of the immunohistochemical markers pertinent to the
diagnosis of melanocytic lesions. There is considerable morphologic overlap between …

The dramatic recent advances in therapy of melanoma require a more personalized and
precise diagnostic approach to aid in clinical decisions. Tissue-based biomarkers in …

As an emerging novel drug delivery system, microneedles (MNs) have a wide range of
applications in the medical field. They can overcome the physiological barriers of the skin …

Background Traditionally, most cutaneous nevi show a gradient of HMB45 (human
melanoma black 45) and negative PRAME (preferentially expressed antigen in melanoma) …

Ambiguous melanocytic lesions/tumors (AMLs) can be simply described as melanocytic
neoplasms that cannot be differentiated as either a melanoma or a nevus. Preferentially …

Proliferative activity in cutaneous melanomas can be appreciated both histopathologically
by counting mitotic figures and immunohistochemically through the Ki67 index, but the …

The majority of melanocytic proliferations can be readily categorized as benign or malignant
based on histologic assessment under the microscope by a trained dermatopathologist …

Dysplastic nevi are distinctive melanocytic lesions in the larger group of atypical nevi. They
often are multiple and sporadic with genetic features intermediate between common …

Background Nevi of special sites (NOSS) are benign melanocytic lesions that occur at
particular sites. Although the histological features of NOSS have been described, their …

Antecedentes: Los nevos de localizaciones especiales (“Nevi of special sites”, NOSS) son
lesiones melanocíticas benignas que se presentaran en localizaciones particulares …