Benefits of metformin in attenuating the hallmarks of aging
AS Kulkarni, S Gubbi, N Barzilai - Cell metabolism, 2020 - cell.com
Biological aging involves an interplay of conserved and targetable molecular mechanisms,
summarized as the hallmarks of aging. Metformin, a biguanide that combats age-related …
summarized as the hallmarks of aging. Metformin, a biguanide that combats age-related …
The continuum of aging and age-related diseases: common mechanisms but different rates
Geroscience, the new interdisciplinary field that aims to understand the relationship between
aging and chronic age-related diseases (ARDs) and geriatric syndromes (GSs), is based on …
aging and chronic age-related diseases (ARDs) and geriatric syndromes (GSs), is based on …
Mitochondrial dysfunction, oxidative stress, and neuroinflammation: Intertwined roads to neurodegeneration
Oxidative stress develops as a response to injury and reflects a breach in the cell's
antioxidant capacity. Therefore, the fine-tuning of reactive oxygen species (ROS) generation …
antioxidant capacity. Therefore, the fine-tuning of reactive oxygen species (ROS) generation …
PPARγ/PGC1α signaling as a potential therapeutic target for mitochondrial biogenesis in neurodegenerative disorders
S Jamwal, JK Blackburn, JD Elsworth - Pharmacology & Therapeutics, 2021 - Elsevier
Neurodegenerative diseases represent some of the most devastating neurological
disorders, characterized by progressive loss of the structure and function of neurons. Current …
disorders, characterized by progressive loss of the structure and function of neurons. Current …
Down syndrome
Trisomy 21, the presence of a supernumerary chromosome 21, results in a collection of
clinical features commonly known as Down syndrome (DS). DS is among the most …
clinical features commonly known as Down syndrome (DS). DS is among the most …
Recent advances in molecular pathways and therapeutic implications targeting mitochondrial dysfunction for Alzheimer's disease
Alzheimer's disease (AD) is a neurodegenerative disorder which leads to mental
deterioration due to aberrant accretion of misfolded proteins in the brain. According to …
deterioration due to aberrant accretion of misfolded proteins in the brain. According to …
Loss of metabolic plasticity underlies metformin toxicity in aged Caenorhabditis elegans
L Espada, A Dakhovnik, P Chaudhari… - Nature …, 2020 - nature.com
Current clinical trials are testing the life-extending benefits of the diabetes drug metformin in
healthy individuals without diabetes. However, the metabolic response of a non-diabetic …
healthy individuals without diabetes. However, the metabolic response of a non-diabetic …
Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome
E Lana-Elola, R Aoidi, M Llorian, D Gibbins… - Science translational …, 2024 - science.org
Down syndrome (DS) is caused by trisomy of human chromosome 21 (Hsa21). DS is a gene
dosage disorder that results in multiple phenotypes including congenital heart defects. This …
dosage disorder that results in multiple phenotypes including congenital heart defects. This …
Systematic proteome and proteostasis profiling in human Trisomy 21 fibroblast cells
Down syndrome (DS) is mostly caused by a trisomy of the entire Chromosome 21 (Trisomy
21, T21). Here, we use SWATH mass spectrometry to quantify protein abundance and …
21, T21). Here, we use SWATH mass spectrometry to quantify protein abundance and …
Metformin Alters Human Host Responses to Mycobacterium tuberculosis in Healthy Subjects
E Lachmandas, C Eckold, J Böhme… - The Journal of …, 2019 - academic.oup.com
Background Metformin, the most widely administered diabetes drug, has been proposed as
a candidate adjunctive host-directed therapy for tuberculosis, but little is known about its …
a candidate adjunctive host-directed therapy for tuberculosis, but little is known about its …