Teeth are found in almost all vertebrates, and they therefore provide a general paradigm for
the study of epithelial organ development and evolution. Here, we review the developmental …

Cell signaling plays a key role in the development of all multicellular organisms. Numerous
studies have established the importance of Hedgehog signaling in a wide variety of …

Winner, 2010 PROSE Award for Excellence in the Biological Sciences. Professional and
Scholarly Publishing division of the Association of American Publishers In this unique book …

Evolutionary developmental biology (evo–devo) explores the mechanistic relationships
between the processes of individual development and phenotypic change during evolution …

All ectodermal organs, eg hair, teeth, and many exocrine glands, originate from two adjacent
tissue layers: the epithelium and the mesenchyme. Similar sequential and reciprocal …

Teeth develop as ectodermal appendages from epithelial and mesenchymal tissues. Tooth
organogenesis is regulated by an intricate network of cell–cell signaling during all steps of …

One motivation in the study of development is the discovery of mechanisms that may guide
evolutionary change. Here we report how development governs relative size and number of …

Drawing on the latest research from around the world, Life of Marsupials explores this
unusual group of mammals covering the extraordinary diversity of forms around the world …

Tooth morphogenesis results from reciprocal interactions between oral epithelium and
ectomesenchyme culminating in the formation of mineralized tissues, enamel, and dentin …

Odontoblasts differentiate from the cells of the dental papilla, and it has been well-
established that their differentiation in developing teeth is induced by the dental epithelium …