Immunomodulatory nanoparticles activate cytotoxic T cells for enhancement of the effect of cancer immunotherapy

K Wells, T Liu, L Zhu, L Yang - Nanoscale, 2024 - pubs.rsc.org
Cancer immunotherapy represents a promising targeted treatment by leveraging the
patient's immune system or adoptive transfer of active immune cells to selectively eliminate …

Smart delivery vehicles for cancer: categories, unique roles and therapeutic strategies

Y Zeng, Y Gao, L He, W Ge, X Wang, T Ma… - Nanoscale …, 2024 - pubs.rsc.org
Chemotherapy and surgery remain the primary treatment modalities for cancers; however,
these techniques have drawbacks, such as cancer recurrence and toxic side effects …

Targeting and monitoring ovarian cancer invasion with an RNAi and peptide delivery system

L Hao, N Boehnke, SK Elledge… - Proceedings of the …, 2024 - National Acad Sciences
RNA interference (RNAi) therapeutics are an emerging class of medicines that selectively
target mRNA transcripts to silence protein production and combat disease. Despite the …

Layer-by-layer polymer functionalization improves nanoparticle penetration and glioblastoma targeting in the brain

AJ Pickering, NG Lamson, MH Marand, W Hwang… - ACS …, 2023 - ACS Publications
Glioblastoma is characterized by diffuse infiltration into surrounding healthy brain tissues,
which makes it challenging to treat. Complete surgical resection is often impossible, and …

Surfactant-Mediated Assembly of Precision-Size Liposomes

IS Pires, JR Suggs, IS Carlo, DS Yun… - Chemistry of …, 2024 - ACS Publications
Liposomes can greatly improve the pharmacokinetics of therapeutic agents due to their
ability to encapsulate drugs and accumulate in target tissues. Considerable effort has been …

Lipid nanoparticle-based mRNA vaccines: a new frontier in precision oncology

EM Jacob, J Huang, M Chen - Precision Clinical Medicine, 2024 - academic.oup.com
The delivery of lipid nanoparticle (LNP)-based mRNA therapeutics has captured the
attention of the vaccine research community as an innovative and versatile tool for treating a …

[HTML][HTML] Engineering approaches for innate immune-mediated tumor microenvironment remodeling

GI Kane, CF Lusi, ML Brassil, PU Atukorale - Immuno-Oncology and …, 2024 - Elsevier
Cancer immunotherapy offers transformative promise particularly for the treatment of lethal
cancers, since a correctly trained immune system can comprehensively orchestrate tumor …

Harnessing biomaterial architecture to drive anticancer innate immunity

MA Davis, E Cho, MH Teplensky - Journal of Materials Chemistry B, 2023 - pubs.rsc.org
Immunomodulation is a powerful therapeutic approach that harnesses the body's own
immune system and reprograms it to treat diseases, such as cancer. Innate immunity is key …

Shifting cold to hot tumors by nanoparticle-loaded drugs and products

I Ahmad, KKA Altameemi, MM Hani, AM Ali… - Clinical and …, 2024 - Springer
Cold tumors lack antitumor immunity and are resistant to therapy, representing a major
challenge in cancer medicine. Because of the immunosuppressive spirit of the tumor …

Charge‐Stabilized Nanodiscs as a New Class of Lipid Nanoparticles

IS Pires, A Hostetler, G Covarrubias, IS Carlo… - Advanced …, 2024 - Wiley Online Library
Nanoparticles have the potential to improve disease treatment and diagnosis due to their
ability to incorporate drugs, alter pharmacokinetics, and enable tissue targeting. While …