More than a century ago, the term 'virus' was introduced to describe infectious agents that
are invisible by light microscopy and capable of passing through sterilizing filters. In addition …

The phylum Nucleocytoviricota includes the largest and most complex viruses known. These
“giant viruses” have a long evolutionary history that dates back to the early diversification of …

Singapore grouper iridovirus (SGIV), one of the nucleocytoviricota viruses (NCVs), is a
highly pathogenic iridovirid. SGIV infection results in massive economic losses to the …

During cell entry, non-enveloped viruses undergo partial uncoating to expose membrane
lytic proteins for gaining access to the cytoplasm. We report that adenovirus uses membrane …

Chloroviruses are large dsDNA, plaque-forming viruses that infect certain chlorella-like
green algae; the algae are normally mutualistic endosymbionts of protists and metazoans …

Giant viruses (Nucleocytoviricota) have a largely conserved lifecycle, yet how they cram their
large genomes into viral capsids is mostly unknown. The major capsid protein and the …

Highlights•Viral factories are dynamic, membranous structures assembled by many
viruses.•Viruses manipulate lipid synthesis, transport and storage to build their factories.•ER …

Vaccinia virus (VACV) has achieved unprecedented success as a live viral vaccine for
smallpox which mitigated eradication of the disease. Vaccinia virus has a complex virion …

Whereas the protein composition and overall shape of several giant virus capsids have
been described, the mechanism by which these large capsids assemble remains enigmatic …

As obligate intracellular parasites, viruses need to hijack their cellular hosts and reprogram
their machineries in order to replicate their genomes and produce new virions. For the direct …