Aptamer-based detection of circulating targets for precision medicine

L Wu, Y Wang, X Xu, Y Liu, B Lin, M Zhang… - Chemical …, 2021 - ACS Publications
The past decade has witnessed ongoing progress in precision medicine to improve human
health. As an emerging diagnostic technique, liquid biopsy can provide real-time …

Recent progress in aptamer discoveries and modifications for therapeutic applications

S Ni, Z Zhuo, Y Pan, Y Yu, F Li, J Liu… - … Applied Materials & …, 2020 - ACS Publications
Aptamers are oligonucleotide sequences with a length of about 25–80 bases which have
abilities to bind to specific target molecules that rival those of monoclonal antibodies. They …

Strategies to manipulate the performance of aptamers in SELEX, post-SELEX and microenvironment

S Qi, N Duan, IM Khan, X Dong, Y Zhang, S Wu… - Biotechnology …, 2022 - Elsevier
Aptamers are short single-stranded DNA or RNA oligonucleotides isolated from randomized
libraries, presenting high affinity and specificity toward targets with similar to antibodies …

Targeting natural killer cells in cancer immunotherapy

C Guillerey, ND Huntington, MJ Smyth - Nature immunology, 2016 - nature.com
Alteration in the expression of cell-surface proteins is a common consequence of malignant
transformation. Natural killer (NK) cells use an array of germline-encoded activating and …

Advancement of the emerging field of RNA nanotechnology

D Jasinski, F Haque, DW Binzel, P Guo - ACS nano, 2017 - ACS Publications
The field of RNA nanotechnology has advanced rapidly during the past decade. A variety of
programmable RNA nanoparticles with defined shape, size, and stoichiometry have been …

Oligonucleotide aptamers: new tools for targeted cancer therapy

H Sun, X Zhu, PY Lu, RR Rosato, W Tan… - Molecular Therapy-Nucleic …, 2014 - cell.com
Aptamers are a class of small nucleic acid ligands that are composed of RNA or single-
stranded DNA oligonucleotides and have high specificity and affinity for their targets. Similar …

Aptamers from random sequence space: Accomplishments, gaps and future considerations

S Qian, D Chang, S He, Y Li - Analytica Chimica Acta, 2022 - Elsevier
Aptamers are molecular recognition elements made of nucleic acids. Diverse synthetic
aptamers have been discovered in a large number of SELEX experiments since 1990. This …

Machine learning guided aptamer refinement and discovery

A Bashir, Q Yang, J Wang, S Hoyer, W Chou… - Nature …, 2021 - nature.com
Aptamers are single-stranded nucleic acid ligands that bind to target molecules with high
affinity and specificity. They are typically discovered by searching large libraries for …

Current advances in aptamers for cancer diagnosis and therapy

S Hori, A Herrera, JJ Rossi, J Zhou - Cancers, 2018 - mdpi.com
Nucleic acid aptamers are single-stranded oligonucleotides that interact with target
molecules with high affinity and specificity in unique three-dimensional structures. Aptamers …

DNA-programed plasmon rulers decrypt single-receptor dimerization on cell membrane

J Wang, J Song, X Zhang, SM Wang… - Journal of the …, 2023 - ACS Publications
Decrypting the dynamics of receptor dimerization on cell membranes bears great
importance in identifying the mechanisms regulating diverse cellular activities. In this regard …