Over the past decade, mRNA modifications have emerged as important regulators of gene
expression control in cells. Fueled in large part by the development of tools for detecting …

Following its transcription, RNA can be modified by> 170 chemically distinct types of
modifications—the epitranscriptome. In recent years, there have been substantial efforts to …

Functional characterization of pseudouridine (Ψ) in mammalian mRNA has been hampered
by the lack of a quantitative method that maps Ψ in the whole transcriptome. We report …

The world of small noncoding RNAs (sncRNAs) is ever-expanding, from small interfering
RNA, microRNA and Piwi-interacting RNA to the recently emerging non-canonical sncRNAs …

Pseudouridine is a modified nucleotide that is prevalent in human mRNAs and is
dynamically regulated. Here, we investigate when in their life cycle mRNAs become …

Pseudouridine (Ψ) is an abundant post-transcriptional RNA modification in ncRNA and
mRNA. However, stoichiometric measurement of individual Ψ sites in human transcriptome …

Over 17 and 160 types of chemical modifications have been identified in DNA and RNA,
respectively. The interest in understanding the various biological functions of DNA and RNA …

Gene regulation depends on dynamic and reversibly modifiable biological and chemical
information in the epigenome/epitranscriptome. Accumulating evidence suggests that …

The “epigenetics” concept was first described in 1942. Thus far, chemical modifications on
histones, DNA, and RNA have emerged as three important building blocks of epigenetic …

Recent advances in pseudouridine detection reveal a complex pseudouridine landscape
that includes messenger RNA and diverse classes of noncoding RNA in human cells. The …