Innate immunosenescence: effect of aging on cells and receptors of the innate immune system in humans
Components of the innate immune response, including neutrophils and macrophages, are
the first line of defense against infections. Their role is to initiate an inflammatory response …
the first line of defense against infections. Their role is to initiate an inflammatory response …
CD56bright natural killer (NK) cells: an important NK cell subset
Human natural killer (NK) cells can be subdivided into different populations based on the
relative expression of the surface markers CD16 and CD56. The two major subsets are …
relative expression of the surface markers CD16 and CD56. The two major subsets are …
Simultaneous epitope and transcriptome measurement in single cells
High-throughput single-cell RNA sequencing has transformed our understanding of complex
cell populations, but it does not provide phenotypic information such as cell-surface protein …
cell populations, but it does not provide phenotypic information such as cell-surface protein …
Tumor immune microenvironment characterization in clear cell renal cell carcinoma identifies prognostic and immunotherapeutically relevant messenger RNA …
Background Tumor-infiltrating immune cells have been linked to prognosis and response to
immunotherapy; however, the levels of distinct immune cell subsets and the signals that …
immunotherapy; however, the levels of distinct immune cell subsets and the signals that …
[HTML][HTML] Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer
The complex interactions between tumors and their microenvironment remain to be
elucidated. Combining large-scale approaches, we examined the spatio-temporal dynamics …
elucidated. Combining large-scale approaches, we examined the spatio-temporal dynamics …
Heterogeneity of human bone marrow and blood natural killer cells defined by single-cell transcriptome
C Yang, JR Siebert, R Burns, ZJ Gerbec… - Nature …, 2019 - nature.com
Natural killer (NK) cells are critical to both innate and adaptive immunity. However, the
development and heterogeneity of human NK cells are yet to be fully defined. Using single …
development and heterogeneity of human NK cells are yet to be fully defined. Using single …
PD-L1-mediated immunosuppression in glioblastoma is associated with the infiltration and M2-polarization of tumor-associated macrophages
Z Zhu, H Zhang, B Chen, X Liu, S Zhang… - Frontiers in …, 2020 - frontiersin.org
There has been no significant improvements for immune checkpoint inhibitors since its first
use. Tumour-associated macrophages (TAMs) are critical mediators in the PD-1/PD-L1 axis …
use. Tumour-associated macrophages (TAMs) are critical mediators in the PD-1/PD-L1 axis …
The trafficking of natural killer cells
C Grégoire, L Chasson, C Luci… - Immunological …, 2007 - Wiley Online Library
Natural killer (NK) cells are large granular lymphocytes of the innate immune system that
participate in the early control of microbial infections and cancer. NK cells can induce the …
participate in the early control of microbial infections and cancer. NK cells can induce the …
Gene regulatory programs conferring phenotypic identities to human NK cells
PL Collins, M Cella, SI Porter, S Li, GL Gurewitz… - Cell, 2019 - cell.com
Natural killer (NK) cells develop from common progenitors but diverge into distinct subsets,
which differ in cytokine production, cytotoxicity, homing, and memory traits. Given their …
which differ in cytokine production, cytotoxicity, homing, and memory traits. Given their …
Human Circulating and Tissue-Resident CD56bright Natural Killer Cell Populations
JE Melsen, G Lugthart, AC Lankester… - Frontiers in …, 2016 - frontiersin.org
Two human natural killer (NK) cell subsets are usually distinguished, displaying the
CD56dimCD16+ and the CD56brightCD16−/+ phenotype. This distinction is based on NK …
CD56dimCD16+ and the CD56brightCD16−/+ phenotype. This distinction is based on NK …