The diverse functions of the DEG/ENaC family: linking genetic and physiological insights

E Kaulich, LJ Grundy, WR Schafer… - The Journal of …, 2023 - Wiley Online Library
The DEG/ENaC family of ion channels was defined based on the sequence similarity
between degenerins (DEG) from the nematode Caenorhabditis elegans and subunits of the …

Ion selectivity in the ENaC/DEG family: A systematic review with supporting analysis

C Vallée, B Howlin, R Lewis - International journal of molecular sciences, 2021 - mdpi.com
The Epithelial Sodium Channel/Degenerin (ENaC/DEG) family is a superfamily of sodium-
selective channels that play diverse and important physiological roles in a wide variety of …

Physiological insight into the conserved properties of Caenorhabditis elegans acid‐sensing degenerin/epithelial sodium channels

E Kaulich, PTN McCubbin, WR Schafer… - The Journal of …, 2023 - Wiley Online Library
Acid‐sensing ion channels (ASICs) are members of the diverse family of
degenerin/epithelial sodium channels (DEG/ENaCs). They perform a wide range of …

Distinct roles for two Caenorhabditis elegans acid-sensing ion channels in an ultradian clock

E Kaulich, T Carroll, BD Ackley, YQ Tang, I Hardege… - Elife, 2022 - elifesciences.org
Biological clocks are fundamental to an organism's health, controlling periodicity of
behaviour and metabolism. Here, we identify two acid-sensing ion channels, with very …

Novel application of a force sensor during sit‐to‐stands to measure dynamic cerebral autoregulation onset

AA Whitaker, ED Vidoni, SE Aaron… - Physiological …, 2022 - Wiley Online Library
Current sit‐to‐stand methods measuring dynamic cerebral autoregulation (dCA) do not
capture the precise onset of the time delay (TD) response. Reduced sit‐to‐stand reactions in …

The epithelial Na+ channel (ENaC) in pancreatic islet β-cells regulates insulin secretion and glucose metabolism

Y Que - 2024 - theses.lib.polyu.edu.hk
Insulin is exclusively produced and secreted by pancreatic islet β-cells, which plays a central
role in regulating glucose metabolism. In response to blood glucose elevation or other …