Reconstructing human-specific regulatory functions in model systems

M Baumgartner, Y Ji, JP Noonan - Current Opinion in Genetics & …, 2024 - Elsevier
Uniquely human physical traits, such as an expanded cerebral cortex and changes in limb
morphology that allow us to use tools and walk upright, are in part due to human-specific …

Overview of chromatin regulatory processes during surface ectodermal development and homeostasis

MC Branch, M Weber, MY Li, P Flora, E Ezhkova - Developmental Biology, 2024 - Elsevier
The ectoderm is the outermost of the three germ layers of the early embryo that arise during
gastrulation. Once the germ layers are established, the complex interplay of cellular …

Sweat gland development requires an eccrine dermal niche and couples two epidermal programs

HL Dingwall, RR Tomizawa, A Aharoni, P Hu, Q Qiu… - Developmental Cell, 2024 - cell.com
Eccrine sweat glands are indispensable for human thermoregulation and, similar to other
mammalian skin appendages, form from multipotent epidermal progenitors. Limited …

Conserved roles of engrailed: patterning tissues and specifying cell types

AL Joyner, JR Ortigão-Farias, T Kornberg - Development, 2024 - journals.biologists.com
More than 40 years ago, studies of the Drosophila engrailed and Hox genes led to major
discoveries that shaped the history of developmental biology. We learned that these genes …

A transient dermal niche and dual epidermal programs underlie sweat gland development

HL Dingwall, RR Tomizawa, A Aharoni, P Hu, Q Qiu… - bioRxiv, 2023 - biorxiv.org
Eccrine glands are mammalian skin appendages indispensable for human
thermoregulation. Like all skin-derived appendages, eccrine glands form from multipotent …