The central role of cytochrome P450 in xenobiotic metabolism—a brief review on a fascinating enzyme family
F Esteves, J Rueff, M Kranendonk - Journal of xenobiotics, 2021 - mdpi.com
Human Cytochrome P450 (CYP) enzymes constitute a superfamily of membrane-bound
hemoproteins that are responsible for the metabolism of a wide variety of clinically …
hemoproteins that are responsible for the metabolism of a wide variety of clinically …
Cytochrome P450 structure, function and clinical significance: a review
P Manikandan, S Nagini - Current drug targets, 2018 - ingentaconnect.com
Background: The cytochrome P450 (CYP) enzymes are membrane-bound hemoproteins
that play a pivotal role in the detoxification of xenobiotics, cellular metabolism and …
that play a pivotal role in the detoxification of xenobiotics, cellular metabolism and …
Functional gene variants of CYP3A4
AN Werk, I Cascorbi - Clinical Pharmacology & Therapeutics, 2014 - Wiley Online Library
Cytochrome P450 3A4 (CYP3A4) is involved in the metabolism of more drugs in clinical use
than any other foreign compound–metabolizing enzyme in humans. Recently, increasing …
than any other foreign compound–metabolizing enzyme in humans. Recently, increasing …
A metabolic stress-inducible miR-34a-HNF4α pathway regulates lipid and lipoprotein metabolism
Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases, but its
underlying mechanism is poorly understood. Here we show that hepatocyte nuclear factor …
underlying mechanism is poorly understood. Here we show that hepatocyte nuclear factor …
Regulation of CAR and PXR Expression in Health and Disease
M Daujat-Chavanieu, S Gerbal-Chaloin - Cells, 2020 - mdpi.com
Pregnane X receptor (PXR, NR1I2) and constitutive androstane receptor (CAR, NR1I3) are
members of the nuclear receptor superfamily that mainly act as ligand-activated transcription …
members of the nuclear receptor superfamily that mainly act as ligand-activated transcription …
The role of CYP450 drug metabolism in precision cardio-oncology
OA Fatunde, SA Brown - International journal of molecular sciences, 2020 - mdpi.com
As many novel cancer therapies continue to emerge, the field of Cardio-Oncology (or onco-
cardiology) has become crucial to prevent, monitor and treat cancer therapy-related …
cardiology) has become crucial to prevent, monitor and treat cancer therapy-related …
Current knowledge of microRNA-mediated regulation of drug metabolism in humans
M Nakano, M Nakajima - Expert opinion on drug metabolism & …, 2018 - Taylor & Francis
Introduction: Understanding the factors causing inter-and intra-individual differences in drug
metabolism potencies is required for the practice of personalized or precision medicine, as …
metabolism potencies is required for the practice of personalized or precision medicine, as …
Pregnane X receptor (PXR) polymorphisms and cancer treatment
A Skandalaki, P Sarantis, S Theocharis - Biomolecules, 2021 - mdpi.com
Pregnane X Receptor (PXR) belongs to the nuclear receptors' superfamily and mainly
functions as a xenobiotic sensor activated by a variety of ligands. PXR is widely expressed …
functions as a xenobiotic sensor activated by a variety of ligands. PXR is widely expressed …
Regulation of drug-metabolizing enzymes in infectious and inflammatory disease: Implications for biologics–small molecule drug interactions
ABSTRACT Introduction: Drug-metabolizing enzymes (DMEs) are primarily down-regulated
during infectious and inflammatory diseases, leading to disruption in the metabolism of small …
during infectious and inflammatory diseases, leading to disruption in the metabolism of small …
[引用][C] Interindividual variability in cytochrome P450–mediated drug metabolism
TS Tracy, AS Chaudhry, B Prasad, KE Thummel… - Drug Metabolism and …, 2016 - ASPET