The standard classification used to define the various cancer genes confines tumor protein
p53 (TP53) to the role of a tumor suppressor gene. However, it is now an indisputable fact …

The cell cycle is composed of a series of steps which can be negatively or postively
regulated by various factors. Chief among the negative regulators is the p53 protein …

TP53 is the most frequently mutated gene in cancer, yet these mutations remain
therapeutically non-actionable. Major challenges in drugging p53 mutations include …

A cellular phosphoprotein with an apparent molecular mass of 90 kd (p90) that forms a
complex with both mutant and wild-type~ 53 protein has been characterized, purified, and …

Mutations in the p53 tumor suppressor are the most frequently observed genetic alterations
in human cancer. The majority of the mutations occur in the core domain which contains the …

Many p53 missense mutations possess dominant-negative activity and oncogenic gain of
function. We report that for structurally destabilized p53 mutants, these effects result from …

THE p53 tumour suppressor gene is the most widely mutated gene in human
tumorigenesis1, 2. p53 encodes a transcriptional activator3–7 whose targets may include …

The INK4a tumor suppressor locus encodes p16 INK4a, an inhibitor of cyclin D-dependent
kinases, and p19 ARF, an alternative reading frame protein that also blocks cell proliferation …

TUMOUR suppressor genes, whose usual function seems to be controlling normal cell
proliferation1, 2, have been implicated in many inherited and sporadic forms of …

Establishment of primary mouse embryo fibroblasts (MEFs) as continuously growing cell
lines is normally accompanied by loss of the p53 or p19ARF tumor suppressors, which act in …