Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that was traditionally
thought to be closely related to genetic and environmental risk factors. Although treatment …

Current classification criteria for definite Antiphospholipid Syndrome (APS) require the use
of three laboratory assays to detect antiphospholipid antibodies (aCL, anti-β2GPI and LA) in …

Systemic lupus erythematosus (SLE) is a protean autoimmune disease where
autoantibodies are frequently targeted against intracellular antigens of the cell nucleus …

Diagnosis of antiphospholipid syndrome (APS) requires the presence of a clinical criterion
(thrombosis and/or pregnancy morbidity), combined with persistently circulating …

The association of antiphospholipid antibodies with thrombosis and obstetric events defines
the antiphospholipid syndrome. A recent systematic review of the literature showed lupus …

Anticardiolipin antibodies (aCL) in the sera of patients with antiphospholipid syndrome
(APS) recognize an altered structure of β2-glycoprotein I (β2-GPI) interacting with solid …

Two neutralizing human mAbs, 2F5 and 4E10, that react with the HIV-1 envelope gp41
membrane proximal region are also polyspecific autoantibodies that bind to anionic …

Presents developments in antiphospholipid syndrome (APS). Details on the
antiphospholipid reactivity; Pathogenesis of APS; Indications for laboratory testing for …

Antiphospholipid antibodies are associated with arterial and venous thrombosis, recurrent
pregnancy loss, and thrombocytopenia. Although the antibodies have not been conclusively …

Oxidized low-density lipoprotein (oxLDL) is thought to promote atherosclerosis through
complex inflammatory and immunologic mechanisms that lead to lipid dysregulation and …