Background Historically, the target in the schistosomiasis control has shifted from infection to
morbidity, then back to infection, but now as a public health problem, before moving on to …

Praziquantel (PZQ) is the drug of choice for the treatment of all forms of schistosomiasis,
although its mechanisms of action are not completely understood. PZQ acts largely on adult …

Control and elimination of the parasitic disease schistosomiasis relies on mass
administration of praziquantel. Whilst these programmes reduce infection prevalence and …

Schistosomiasis is a parasitic disease caused by trematode blood flukes of the genus
Schistosoma, affecting over 250 million people mainly in the tropics. Clinically, the disease …

Schistosomiasis is a neglected tropical disease (NTD) caused by parasitic trematodes
belonging to the Schistosoma genus. The mainstay of schistosomiasis control is the delivery …

Background: The World Health Organization recommends efficacy and safety surveillance of
anti-helminths used in mass drug administration campaigns. We evaluated the effectiveness …

Do mutations required for adaptation occur de novo, or are they segregating within
populations as standing genetic variation? This question is key to understanding adaptive …

Background Most studies assessing praziquantel (PZQ) efficacy have used relatively
insensitive diagnostic methods, thereby overestimating cure rate (CR) and intensity …

Background Freshwater snails are the intermediate hosts of a large variety of trematode
flukes such as Schistosoma mansoni responsible for one of the most important parasitic …

Background Preventive chemotherapy with praziquantel (PZQ) is the cornerstone of
schistosomiasis control. However, a single dose of PZQ (40 mg/kg) does not cure all …