Peptide-oligonucleotide conjugates (POCs) represent one of the increasingly successful
albeit costly approaches to increasing the cellular uptake, tissue delivery, bioavailability …

Olignucleotide-based drugs show promise as a novel form of chemotherapy. Among the
hurdles that have to be overcome on the way of applicable nucleic acid therapeutics …

Oligonucleotides constitute a class of potential therapeutic agents that can be used to target
mRNA (antisense strategy), double-stranded DNA (triple-helix strategy), and even proteins …

Ever since the observation that synthetic oligonucleotides and their modified analogues can
be used successfully to modulate the functions of specific genes, 1, 2 the research on …

A new strategy has been developed for conjugation of peptides to oligonucleotides. The
method is based on the “native ligation” of an N-terminal thioester-functionalized peptide to …

The use of synthetic oligonucleotides and their mimics to inhibit gene expression by
hybridizing with their target sequences has been hindered by their poor cellular uptake and …

The synthesis and characterization of photocleavable peptide-DNA conjugates is described
along with their use as photocleavable mass marker (PCMM) hybridization probes for the …

Antisense and small interfering RNA (siRNA) oligonucleotides have been recognized as
powerful therapeutic compounds for targeting mRNAs and inducing their degradation …

The synthesis of oligonucleotides carrying nuclear localization peptide sequences is
described using two strategies: first, oligonucleotides carrying a thiol group at the 5 'end …

Here we describe the preparation of 25 beaded polystyrene− poly (ethylene glycol) graft
copolymers from six spectroscopically active styrene monomers: styrene, 2, 5 …