Highlights•Antibody-independent epitope prediction methods have a poor
performance.•Methods predicting an epitope for a certain antibody were recently …

We describe Rosetta-based computational protocols for predicting the 3D structure of an
antibody from sequence (RosettaAntibody) and then docking the antibody to protein …

A hallmark of the adaptive immune system is the specificity of B cell and T cell responses.
Mechanistically, this feature relies on the fact that the two genes that encode B cell and T cell …

Computational modeling of antibody structures plays a critical role in therapeutic antibody
design. Several antibody modeling pipelines exist, but no freely available methods currently …

B-cells can neutralize pathogenic molecules by targeting them with extreme specificity using
receptors secreted or expressed on their surface (antibodies). This is achieved via molecular …

The accurate structural modeling of B-and T-cell receptors is fundamental to gain a detailed
insight in the mechanisms underlying immunity and in developing new drugs and therapies …

Improved understanding of properties that mediate protein solubility and resistance to
aggregation are important for developing biopharmaceuticals, and more generally in …

abstract Antibody humanization describes the procedure of grafting a non-human antibody's
complementarity-determining regions, ie, the variable loop regions that mediate specific …

The BCL-2 protein family plays a critical role in regulating cellular commitment to
mitochondrial apoptosis. Pro-apoptotic Bcl-2-associated X protein (BAX) is an executioner …

Human B cells produce antibodies, which bind to their cognate antigen based on distinct
molecular properties of the antibody CDR loop. We have analysed a set of 10 antibodies …