Abstract Interleukin-33 (IL-33)—a member of the IL-1 family—was originally described as an
inducer of type 2 immune responses, activating T helper 2 (TH2) cells and mast cells. Now …

Summary Interleukin (IL)‐33 is a key cytokine involved in type 2 immunity and allergic
airway diseases. Abundantly expressed in lung epithelial cells, IL‐33 plays critical roles in …

Transgenic mice expressing the mouse interleukin 33 (IL-33) gene driven by a keratin 14
promoter were generated. The skin-selective expression of the IL-33 gene was enhanced …

Alternatively activated macrophages (AAM) play a crucial role in type 2 immunity. Mice
deficient in ST2, a receptor for the latest member of the IL-1 family, IL-33, have impaired type …

Innate immunity provides the first line of response to invading pathogens and a variety of
environmental insults. Recent studies identified novel subsets of innate lymphoid cells that …

Allergic rhinitis (AR) is a common disorder affecting up to 40% of the population worldwide
and it usually persists throughout life. Nasal epithelial barrier constitutes the first line of …

BACKGROUND: We reported previously that serum levels of IL-33 are significantly
increased in patients with allergic rhinitis (AR). However, very little is known about the role of …

Seasonal allergic rhinitis (SAR) caused by Japanese cedar pollen (JCP; ie, sugi-pollinosis)
is the most common disease in Japan and has been considered a national affliction. More …

IL-33 has emerged as an important mediator in the immunopathogenesis of allergy and
asthma. However, the role of IL-33 in eosinophil-mediated inflammation has not been fully …

Atopic dermatitis (AD) is a common chronic pruritic inflammatory skin disorder characterized
by recurrent eczematous lesions. Interleukin (IL)− 33, a cytokine of the IL-1 family, was found …