Schistosomiasis is a major cause of morbidity in humans invoked by chronic infection with
parasitic trematodes of the genus Schistosoma. Schistosomes have a complex life-cycle …

Dendritic cells (DCs) are critical for the activation of naïve CD4+ T cells and are considered
professional antigen-presenting cells (APCs), as are macrophages and B cells. Recently …

Th2–eosinophil immune responses are well known for mediating host defence against
helminths. Herein we describe a function of Th2–eosinophil responses in counteracting the …

Helminth infections represent a significant public health concern resulting in devastating
morbidity and economic consequences across the globe. Helminths migrate through …

Schistosomiasis is the second most debilitating neglected tropical disease globally after
malaria, with no available therapy to control disease-driven immunopathology. Although …

Infection of mice with the gastrointestinal helminth Nippostrongylus brasiliensis elicits
profound local proliferation and accumulation of type 2 innate lymphoid cells (ILC2s) in the …

Parasitic worms (helminths) developed various immunoregulatory mechanisms to
counteract the immune system of their host. The increasing identification and …

Pulmonary arterial hypertension (PAH) is a disease of the lung blood vessels that results in
right heart failure. PAH is thought to occur in about 5% to 10% of patients with hepatosplenic …

Basophils are functionally closely related to mast cells. Both cell types express the high-
affinity IgE receptor (FcεRI) and rapidly release preformed mediator from intracellular stores …

Abstract Background IL‐4 and IL‐13 play a crucial role during allergic asthma. Both
cytokines can be produced by T cells and a variety of cell types of the innate immune …