Hypoxia is a common feature of solid tumors, and develops because of the rapid growth of
the tumor that outstrips the oxygen supply, and impaired blood flow due to the formation of …

Recent biomedical discoveries have revolutionized the concept and understanding of
carcinogenesis, a complex and multistep phenomenon which involves accretion of genetic …

The CRISPR/Cas9 system is an RNA-based adaptive immune system in bacteria and
archaea. Various studies have shown that it is possible to target a wide range of human …

Colorectal cancer (CRC) is one of malignant afflictions burdening people worldwide, mainly
caused by shortages of effective medical intervention and poorly mechanistic understanding …

The nuclear speckle-type pox virus and zinc finger (POZ) protein (SPOP), a representative
substrate-recognition subunit of the cullin-RING E3 ligase, has been characterized to play a …

Clear evidence shows that tumors could secrete microRNAs (miRNAs) via exosomes to
modulate the tumor microenvironment (TME). However, the mechanisms sorting specific …

The initiation and progression of cancer is dependent on the acquisition of mutations in
oncogenes or tumor suppressor genes that ultimately leads to the dysregulation of key …

Long non-coding RNAs (lncRNAs) are longer than 200 nts non-coding transcripts and have
recently emerged as one of the largest and significantly diverse RNA families whereas …

Abstract microRNAs are small, noncoding RNA that negatively regulate gene expression.
Since their discovery in 1993, approximately 2500 human mature microRNAs have been …

Vitamin D 3 is the precursor of 1α, 25-dihydroxyvitamin D 3 (1, 25 (OH) 2 D 3), a pleiotropic
hormone that is a major regulator of the human genome. 1, 25 (OH) 2 D 3 modulates the …