The antibacterial activity of fatty acids (FA) is well known in the literature and represents a
promising option for developing the next-generation of antibacterial agents to treat a broad …

Thiazoles, their benzofused systems, and thiazolidinone derivatives are widely recognized
as nuclei of great value for obtaining molecules with various biological activities, including …

Antimicrobial resistance is one of the greatest challenges facing the world today. In the
United States alone, it is responsible for the death of more than 20,000 people each year …

Bacterial DNA gyrase and topoisomerase IV control the topological state of DNA during
replication and are validated targets for antibacterial drug discovery. Starting from our …

The synthesis of sulfur heterocycles via the construction of C–S bonds has received
considerable attention due to their biological value and extensive pharmaceutical …

A series of 1-substituted benzyl-4-[1-phenyl-3-(4-methyl-2-aryl-1, 3-thiazol-5-yl)-1H-pyrazol-
4-yl]-1H-1, 2, 3-triazole derivatives (7a-y) have been synthesized by click reaction of 5-(4 …

Mycobacterium tuberculosis (Mtb) is an obligate aerobe that is capable of long-term
persistence under conditions of low oxygen tension. A series of thiazolyl-pyrazole …

A new series of dual low nanomolar benzothiazole inhibitors of bacterial DNA gyrase and
topoisomerase IV were developed. The resulting compounds show excellent broad …

The present work describes the synthesis of five novel heterocyclic azo dyes (4a-4e) through
conventional diazo-coupling reaction of 4, 5, 6, 7-tetrahydro-1, 3-benzothiazole with various …

The rapid spread of bacterial infection caused by Staphylococcus aureus has become a
problem to public health despite the presence of past trials devoted to controlling the …