It has long been known that endothelial Ca2+ signals drive angiogenesis by recruiting
multiple Ca2+-sensitive decoders in response to pro-angiogenic cues, such as vascular …

The acquired ability to induce the formation of a functional vasculature is a hallmark of
cancer. Blood vessels in tumors are formed through various mechanisms, among the most …

Background: Delayed wound healing is a diverse, multifactorial, complex and inter-related
complication of diabetes resulting in significant clinical morbidity. Hesperidin possesses …

Our research introduces the natural flavonoid naringenin as a novel inhibitor of an emerging
class of intracellular channels, Two-Pore Channel 2 (TPC2), as shown by …

The recent discovery of MRGPRX2 explains mast cell (MC)-dependent symptoms
independently of FcεRI-activation. Because of its novelty, signaling cascades triggered by …

The formation and progression of tumors in humans are linked to the abnormal development
of new blood vessels known as neo-angiogenesis. Angiogenesis is a broad word that …

Intracellular Ca2+ signaling drives angiogenesis and vasculogenesis by stimulating
proliferation, migration, and tube formation in both vascular endothelial cells and endothelial …

A monolayer of endothelial cells lines the innermost surface of all blood vessels, thereby
coming into close contact with every region of the body and perceiving signals deriving from …

The epiretinal membrane (ERM) is a pathological tissue formed at the vitreoretinal interface.
The formation of this tissue is associated with numerous symptoms related to disturbances of …

Angiogenesis is a multistep process that controls endothelial cells (ECs) functioning to form
new blood vessels from preexisting vascular beds. This process is tightly regulated by pro …