Longitudinal in-vivo quantification of tumour microvascular heterogeneity by optical coherence angiography in pre-clinical radiation therapy

N Allam, W Jeffrey Zabel, V Demidov, B Jones… - Scientific Reports, 2022 - nature.com
Stereotactic body radiotherapy (SBRT) is an emerging cancer treatment due to its logistical
and potential therapeutic benefits as compared to conventional radiotherapy. However, its …

Radiation-induced alterations in multi-layered, in-vitro skin models detected by optical coherence tomography and histological methods

L Bromberger, B Heise, K Felbermayer… - PloS one, 2023 - journals.plos.org
Background Inflammatory skin reactions and skin alterations are still a potential side effect in
radiation therapy (RT), which also need attention for patients' health care. Method In a pre …

Bridging the macro to micro resolution gap with angiographic optical coherence tomography and dynamic contrast enhanced MRI

WJ Zabel, N Allam, WD Foltz, C Flueraru, E Taylor… - Scientific Reports, 2022 - nature.com
Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) is emerging as a
valuable tool for non-invasive volumetric monitoring of the tumor vascular status and its …

Spatial and temporal patterns in dynamic-contrast enhanced intraoperative fluorescence imaging enable classification of bone perfusion in patients undergoing leg …

X Han, V Demidov, VS Vaze, S Jiang… - Biomedical Optics …, 2022 - opg.optica.org
Dynamic contrast-enhanced fluorescence imaging (DCE-FI) classification of tissue viability
in twelve adult patients undergoing below knee leg amputation is presented. During …

Antimicrobial PDT effectively destroys E. coli and E. faecalis orthopaedic biofilms compared to low efficacy of a tobramycin and vancomycin mixture: an in vitro study …

V Demidov, MC Bond, IL Gitajn… - … , and Treatment of …, 2023 - spiedigitallibrary.org
In orthopaedic trauma surgery, biofilms account for up to 65% of all infections, typically
showing increased resistance to antibiotics, and thus novel anti-biofilm approaches need to …

Low-cost 3D-printed tools towards robust longitudinal multi-modal pre-clinical imaging

N Allam, IA Vitkin, E Taylor - bioRxiv, 2023 - biorxiv.org
Window chamber models enable a range of preclinical in-vivo optical studies with high
spatial resolution and contrast, most notably probing the tumour microenvironment (TME) …

Informative OCT radiomic features towards improved melanoma detection

B Łukas, M Tsoukas, K Avanaki - Photonics in Dermatology …, 2022 - spiedigitallibrary.org
Survival from melanoma, the deadliest form of skin cancer, depends heavily on early
detection. Several non-invasive medical imaging modalities have been developed to detect …

Automated texture-based segmentation of hair follicles in volumetric optical coherence tomography images of dermatologic burn wounds

N Demidova, TM Cannon… - 2023 Photonics …, 2023 - ieeexplore.ieee.org
Adnexal structures in skin, such as sweat glands and hair follicles, harbor stem cells that are
indispensable for wound healing following acute injuries such as burns of various degrees …

Intraoperative Quantification of Bone Perfusion in Lower Extremity Injury Surgery

X Han - 2023 - search.proquest.com
Orthopaedic surgery is one of the most common surgical categories. In particular, lower
extremity injuries sustained from trauma can be complex and life-threatening injuries that …

OCT-specific signal features for semi-automatic semantic scans annotation and segmentations

AA Sovetsky, AL Matveyev, AA Zykov… - Optics in Health …, 2023 - spiedigitallibrary.org
Computer vision approaches have grown exponentially in recent years. Training AI models
often requires annotated data. To increase effectiveness of this procedure one can use semi …