Adverse drug reactions (ADRs) are considered as an important cause of morbidity and
mortality. The hypersensitivity reactions are immune-mediated ADRs, which are dose …

The precise evaluation of patients with NSAIDs hypersensitivity following established
guidelines will improve not only our understanding but also the management of these …

The effect of aspirin desensitization (AD) on immunologic profile of patients with AERD has
been poorly understood. This study is aimed at investigating the effect of AD on clinical and …

This study aimed to investigate the efficacy and the underlining mechanism of aspirin
desensitization among patients with Aspirin Exacerbated Respiratory Disease (AERD) …

Background The pathogenesis of chronic rhinosinusitis with nasal polyps is largely
unknown. Previous studies have given valuable information about genetic variants …

The HLA-DRB1 gene encodes a protein that is essential for the immune system. This gene
is important in organ transplant rejection and acceptance, as well as multiple sclerosis …

Background: Identification of asthma phenotypes enables a better understanding and
management of this heterogeneous disease. Studies have reported associations between …

Severe cutaneous adverse drug reaction (SCAR) is considered to be a multifactorial drug
side effect. This study was designed to investigate the epidemiology and human leukocyte …

Aspirin intolerance is a severe and rare asthmatic endotype, with prevalence rates of 10% in
the adult asthmatic population and up to 25% in patients with severe, persistent asthma. 1–4 …

Aspirin exacerbated respiratory disease (AERD) is a condition caused by increased
bronchoconstriction in people with asthma after taking aspirin or another NSAID. Molecular …