Despite advances in machine learning-based protein structure prediction, we are still far
from fully understanding how proteins fold into their native conformation. The conventional …

There is an increasing amount of evidence that biomolecular condensates are linked to
neurodegenerative diseases associated with protein aggregation, such as Alzheimer's …

The ubiquitous heat shock protein 70 (HSP70) family consists of ATP-dependent molecular
chaperones, which perform numerous cellular functions that affect almost all aspects of the …

Amyloid-like aggregates of the microtubule-associated protein Tau are associated with
several neurodegenerative disorders including Alzheimer's disease. The existence of …

Chaperone-mediated autophagy (CMA) is a lysosome-dependent selective degradation
pathway implicated in the pathogenesis of cancer and neurodegenerative diseases …

Stresses such as heat shock trigger the formation of protein aggregates and the induction of
a disaggregation system composed of molecular chaperones. Recent work reveals that …

Aberrant phase separation of globular proteins is associated with many diseases. Here, we
use a model protein system to understand how the unfolded states of globular proteins drive …

Alpha-synuclein (αSyn) is a protein involved in neurodegenerative disorders including
Parkinson's disease. Amyloid formation of αSyn can be modulated by the 'P1 …

Protein O-glycosylation is widely identified in various proteins involved in diverse biological
processes. Recent studies have demonstrated that O-glycosylation plays crucial and …

Sorafenib, a tyrosine kinase inhibitor, has an important antitumor effect as a ferroptosis
inducer in multiple cancers, including gastric cancer (GC). However, the status of sorafenib …