Covering: 31st December 2004Natural product and natural product-derived compounds that
are being evaluated in clinical trials or in registration (current 31 December 2004) have …

Covering: up to 2014 In this review we investigate the use of complex ester fragment
couplings within natural product total synthesis campaigns. We first outline the different …

A review of efforts that have provided total syntheses of vancomycin and related
glycopeptide antibiotics, their agylcons, and key analogues is provided. It is a tribute to …

Ever since the world‐shaping discovery of penicillin, nature's molecular diversity has been
extensively screened for new medications and lead compounds in drug discovery. The …

This article provides an overview on the recent achievements to combat Gram-positive
bacteria and the mechanisms related to antimicrobial activity and bacterial resistance …

Covering: 2000 up to 2020 This review presents select recent advances in the medicinal
chemistry of complex natural products that are prepared by total synthesis. The underlying …

The lipoglycodepsipeptide antibiotic ramoplanin is proposed to inhibit bacterial cell wall
biosynthesis by binding to intermediates along the pathway to mature peptidoglycan, which …

The natural product glycopeptides vancomycin and teicoplanin have come to play a
significant role in the therapy for Gram-positive bacterial infections. In particular vancomycin …

Before the introduction of antibiotics in the 1940s and 1950s, patients with
bacteremiasbacteria in the blood streamshad almost no chance of survival. 1, 2 Antibiotics …

A Perspective of work in our laboratory on the examination of biologically active compounds,
especially natural products, is presented. In the context of individual programs and along …